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Tbio
RBFOX2
RNA binding protein fox-1 homolog 2

Protein Summary
Description
RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (By similarity). RNA-binding protein that seems to act as a coregulatory factor of ER-alpha. This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefS ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262829
  • ENSP00000262829
  • ENSG00000100320
  • ENST00000405409
  • ENSP00000384944
  • ENST00000414461
  • ENSP00000407855
  • ENST00000416721
  • ENSP00000405651
  • ENST00000438146
  • ENSP00000413035
  • ENST00000449924
  • ENSP00000391670
  • ENST00000618140
  • ENSP00000482053
  • ENSG00000277564
  • ENST00000619768
  • ENSP00000479761
  • ENST00000626107
  • ENSP00000485984
  • ENST00000627946
  • ENSP00000487477
  • ENST00000631365
  • ENSP00000485711

Symbol
  • FOX2
  • HRNBP2
  • RBM9
  • RTA
  • RTA
  • fxh
  • FOX2
  • RBM9
  • Fox-2
  • HNRBP2
  • HRNBP2
  • dJ106I20.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
transcription factor perturbation
0.88
histone modification site profile
0.86
microRNA
0.76
interacting protein
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.11   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 227   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.11   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (138)
TRMT61A
Tbio
Family:  Enzyme
Novelty:  0.04443394
p_int:  0.999999756
p_ni:  2.44e-7
Score:  0.313
Data Source:  BioPlex,STRINGDB
FAM136A
Tdark
Novelty:  0.4050275
p_int:  0.9999956
p_ni:  0.0000044
Score:  0.193
Data Source:  BioPlex,STRINGDB
RBPMS
Tbio
Novelty:  0.01727259
p_int:  0.999981011
p_ni:  0.0000188
p_wrong:  1.89e-7
Score:  0.823
Data Source:  BioPlex,STRINGDB
FNDC3B
Tbio
Novelty:  0.03060075
p_int:  0.999966973
p_ni:  0.000032964
p_wrong:  6.3e-8
Score:  0.198
Data Source:  BioPlex,STRINGDB
RBM38
Tbio
Novelty:  0.03491566
p_int:  0.999958089
p_ni:  0.000041318
p_wrong:  5.94e-7
Score:  0.576
Data Source:  BioPlex,STRINGDB
PUM2
Tbio
Novelty:  0.01849765
p_int:  0.999932096
p_ni:  0.000067891
p_wrong:  1.3e-8
Score:  0.673
Data Source:  BioPlex,STRINGDB
COPRS
Tbio
Novelty:  0.03545787
p_int:  0.99989912
p_ni:  0.000062219
p_wrong:  0.000038662
Data Source:  BioPlex
PUM1
Tbio
Novelty:  0.01536723
p_int:  0.999646638
p_ni:  0.000353362
Score:  0.552
Data Source:  BioPlex,STRINGDB
DPH2
Tbio
Novelty:  0.04268301
p_int:  0.999643918
p_ni:  0.000339815
p_wrong:  0.000016267
Data Source:  BioPlex
JMJD4
Tbio
Novelty:  0.09951585
p_int:  0.999530414
p_ni:  0.000469232
p_wrong:  3.54e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
FGFR2 alternative splicing (R-HSA-6803529)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
FGFR2 alternative splicing
Reactome
Signal Transduction
Reactome
Signaling by FGFR
Reactome
Signaling by FGFR2
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
FGFR2 alternative splicing
Signal Transduction
Signaling by FGFR
Signaling by FGFR2
Signaling by Receptor Tyrosine Kinases
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
31.2
red blood cell distribution width
1
1
1
31.2
mathematical ability
1
1
1
28.1
mathematical ability
1
1
1
28.1
sex hormone-binding globulin measurement
2
1
2
13.8
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
31.2
red blood cell distribution width
1
31.2
mathematical ability
1
28.1
mathematical ability
1
28.1
sex hormone-binding globulin measurement
2
13.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA binding fox-1 homolog 2
VGNC:10113
741083
Macaque
RNA binding fox-1 homolog 2
693642
Mouse
MGI:1933973
93686
Rat
RGD:1311838
362950
Dog
RNA binding fox-1 homolog 2
VGNC:45399
481281
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA binding fox-1 homolog 2
Macaque
RNA binding fox-1 homolog 2
Mouse
Rat
Dog
RNA binding fox-1 homolog 2
Publication Statistics
PubMed Score 128.11
PubMed score by year
PubTator Score 126.65
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title