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Tbio
RBFOX2
RNA binding protein fox-1 homolog 2

Protein Summary
Description
RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis (By similarity). RNA-binding protein that seems to act as a coregulatory factor of ER-alpha. This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefS ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262829
  • ENSP00000262829
  • ENSG00000100320
  • ENST00000405409
  • ENSP00000384944
  • ENST00000414461
  • ENSP00000407855
  • ENST00000416721
  • ENSP00000405651
  • ENST00000438146
  • ENSP00000413035
  • ENST00000449924
  • ENSP00000391670
  • ENST00000618140
  • ENSP00000482053
  • ENSG00000277564
  • ENST00000619768
  • ENSP00000479761
  • ENST00000626107
  • ENSP00000485984
  • ENST00000627946
  • ENSP00000487477
  • ENST00000631365
  • ENSP00000485711

Symbol
  • FOX2
  • HRNBP2
  • RBM9
  • RTA
  • RTA
  • fxh
  • FOX2
  • RBM9
  • Fox-2
  • HNRBP2
  • HRNBP2
  • dJ106I20.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
transcription factor perturbation
0.88
histone modification site profile
0.86
microRNA
0.76
interacting protein
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.4   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 227   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.4   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0