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Tbio
RBBP7
Histone-binding protein RBBP7

Protein Summary
Description
Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among severa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380084
  • ENSP00000369424
  • ENSG00000102054
  • ENST00000380087
  • ENSP00000369427

Symbol
  • RBAP46
  • RbAp46
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
1
protein complex
1
disease perturbation
0.93
transcription factor perturbation
0.91


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.7   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 343   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.7   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 343   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (476)
MTA1
Tbio
Family:  TF
Novelty:  0.00464618
p_int:  1
Score:  0.997
Data Source:  BioPlex,STRINGDB
SINHCAF
Tdark
Novelty:  0.18692832
p_int:  1
Score:  0.958
Data Source:  BioPlex,STRINGDB
SUZ12
Tbio
Novelty:  0.00402353
p_int:  0.999999999
p_ni:  1e-9
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
ZNF219
Tbio
Family:  TF
Novelty:  0.17515242
p_int:  0.999999999
p_ni:  1e-9
Score:  0.825
Data Source:  BioPlex,STRINGDB
PHF12
Tbio
Family:  Epigenetic
Novelty:  0.00240295
p_int:  0.999999974
p_ni:  2.5e-8
p_wrong:  1e-9
Score:  0.976
Data Source:  BioPlex,STRINGDB
MTF2
Tbio
Family:  Epigenetic
Novelty:  0.01152147
p_int:  0.999999969
p_ni:  2e-8
p_wrong:  1.1e-8
Score:  0.968
Data Source:  BioPlex,Reactome,STRINGDB
ZNF521
Tbio
Family:  TF
Novelty:  0.02133991
p_int:  0.999999963
p_ni:  3.1e-8
p_wrong:  6e-9
Score:  0.774
Data Source:  BioPlex,STRINGDB
ZNF512B
Tbio
Family:  TF
Novelty:  0.0976969
p_int:  0.999999954
p_ni:  4.3e-8
p_wrong:  3e-9
Score:  0.729
Data Source:  BioPlex,STRINGDB
CHD5
Tbio
Family:  Epigenetic
Novelty:  0.06408395
p_int:  0.999999917
p_ni:  8.3e-8
Score:  0.947
Data Source:  BioPlex,STRINGDB
KDM5A
Tchem
Family:  TF; Epigenetic
Novelty:  0.00953355
p_int:  0.999999903
p_ni:  3.1e-8
p_wrong:  6.6e-8
Score:  0.857
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (47)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 39
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Cell Cycle
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Cell Cycle
Cellular Senescence
Cellular responses to external stimuli
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
5
3
5
81.9
prostate specific antigen measurement
1
1
1
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
5
81.9
prostate specific antigen measurement
1
57.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RB binding protein 7, chromatin remodeling factor
VGNC:1203
465518
Macaque
RB binding protein 7, chromatin remodeling factor
713843
Mouse
MGI:1194910
245688
Rat
RGD:620125
83712
Dog
RB binding protein 7, chromatin remodeling factor
VGNC:45393
480854
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RB binding protein 7, chromatin remodeling factor
Macaque
RB binding protein 7, chromatin remodeling factor
Mouse
Rat
Dog
RB binding protein 7, chromatin remodeling factor
Publication Statistics
PubMed Score 47.70
PubMed score by year
PubTator Score 36.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title