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Tbio
RBBP4
Histone-binding protein RBBP4

Protein Summary
Description
Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. It is presen ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373485
  • ENSP00000362584
  • ENSG00000162521
  • ENST00000373493
  • ENSP00000362592
  • ENST00000414241
  • ENSP00000398242
  • ENST00000458695
  • ENSP00000396057

Symbol
  • RBAP48
  • NURF55
  • RBAP48
  • lin-53
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein complex
1
molecular function
0.99
hub protein
0.98
transcription factor perturbation
0.97


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.45   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 438   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.45   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 438   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (411)
MTA1
Tbio
Family:  TF
Novelty:  0.00464618
p_int:  0.999911349
p_ni:  0.000088651
Score:  0.999
Data Source:  BioPlex,STRINGDB
ZNF219
Tbio
Family:  TF
Novelty:  0.17515242
p_int:  0.999677409
p_ni:  0.000322591
Score:  0.753
Data Source:  BioPlex,STRINGDB
SINHCAF
Tdark
Novelty:  0.18692832
p_int:  0.998712718
p_ni:  0.001287282
Score:  0.928
Data Source:  BioPlex,STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
p_int:  0.99847814
p_ni:  0.00152186
Score:  0.995
Data Source:  BioPlex,STRINGDB
ASF1B
Tbio
Novelty:  0.05716701
p_int:  0.99789819
p_ni:  0.00210181
Score:  0.833
Data Source:  BioPlex,STRINGDB
ASF1A
Tchem
Novelty:  0.02544466
p_int:  0.997561566
p_ni:  0.002438434
Score:  0.799
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.99149685
p_ni:  0.00850315
Score:  0.998
Data Source:  BioPlex,STRINGDB
LIN9
Tbio
Novelty:  0.01112853
p_int:  0.986642801
p_ni:  0.013357199
Score:  0.995
Data Source:  BioPlex,STRINGDB
HIST1H3A
Tbio
Novelty:  0.00991842
p_int:  0.983523907
p_ni:  0.016476093
Score:  0.59
Data Source:  BioPlex,Reactome,STRINGDB
HIST1H4A
Tchem
Novelty:  0.00279614
p_int:  0.982649536
p_ni:  0.017350464
Score:  0.753
Data Source:  BioPlex,Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (59)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 47
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cellular Senescence
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Cell Cycle
Cell Cycle, Mitotic
Cellular Senescence
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
63.4
body mass index
1
1
1
48.8
visceral adipose tissue measurement
1
1
1
38.2
free cholesterol:total lipids ratio
1
1
1
12.1
very low density lipoprotein cholesterol measurement
1
1
1
12.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
63.4
body mass index
1
48.8
visceral adipose tissue measurement
1
38.2
free cholesterol:total lipids ratio
1
12.1
very low density lipoprotein cholesterol measurement
1
12.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
RB binding protein 4, chromatin remodeling factor
708710
Mouse
MGI:1194912
19646
Rat
RGD:1593768
313048
Dog
RB binding protein 4, chromatin remodeling factor
VGNC:45391
478149
Horse
RB binding protein 4, chromatin remodeling factor
VGNC:22220
100070175
Species
Name
OMA
EggNOG
Inparanoid
Macaque
RB binding protein 4, chromatin remodeling factor
Mouse
Rat
Dog
RB binding protein 4, chromatin remodeling factor
Horse
RB binding protein 4, chromatin remodeling factor
Publication Statistics
PubMed Score 107.45
PubMed score by year
PubTator Score 881.05
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title