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Tchem
RB1
Retinoblastoma-associated protein

Protein Summary
Description
Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Up ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267163
  • ENSP00000267163
  • ENSG00000139687

Symbol
  • RB
  • pRb
  • OSRC
  • pp110
  • p105-Rb
  • PPP1R130
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
hub protein
1
kinase
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1525.29   (req: < 5)
Gene RIFs: 692   (req: <= 3)
Antibodies: 3155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1525.29   (req: >= 5)
Gene RIFs: 692   (req: > 3)
Antibodies: 3155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 66
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (373)
CITED1
Tbio
Novelty:  0.01956689
p_int:  0.999931409
p_ni:  0.000068591
Data Source:  BioPlex
TFDP2
Tbio
Family:  TF
Novelty:  0.14331363
p_int:  0.998473366
p_ni:  0.001526634
Score:  0.975
Data Source:  BioPlex,Reactome,STRINGDB
CTBP1
Tbio
Novelty:  0.00243818
p_int:  0.995985624
p_ni:  0.004014376
Score:  0.936
Data Source:  BioPlex,STRINGDB
RFC5
Tbio
Novelty:  0.03987481
p_int:  0.990478834
p_ni:  0.009521166
Score:  0.247
Data Source:  BioPlex,STRINGDB
C3orf62
Tdark
Novelty:  1.85670012
p_int:  0.981678345
p_ni:  0.018321655
Score:  0.209
Data Source:  BioPlex,STRINGDB
CDK13
Tchem
Family:  Kinase
Novelty:  0.03084808
p_int:  0.948203644
p_ni:  0.051796354
p_wrong:  2e-9
Score:  0.157
Data Source:  BioPlex,STRINGDB
TFDP3
Tbio
Family:  TF
Novelty:  0.00223003
p_int:  0.939017736
p_ni:  0.060982241
p_wrong:  2.3e-8
Score:  0.872
Data Source:  BioPlex,STRINGDB
PPAN
Tbio
Novelty:  0.01063709
p_int:  0.922780878
p_ni:  0.077219122
Data Source:  BioPlex
RFPL2
Tdark
Novelty:  1.87914964
p_int:  0.864705395
p_ni:  0.135294351
p_wrong:  2.54e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
CCL19
Tbio
Novelty:  0.00169711
p_int:  0.856132083
p_ni:  0.142556872
p_wrong:  0.001311045
Data Source:  BioPlex
Nearest Tclin Targets (5)
Explore Nearest Tclin Targets
1 – 5 of 5
CDK6
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  18
more:  14 more common pathways
ABL1
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  3
HDAC2
Tclin
Family:  Epigenetic
KEGG Distance:  1
Common Pathways:  6
more:  2 more common pathways
HDAC1
Tclin
Family:  Epigenetic
KEGG Distance:  1
Common Pathways:  6
more:  2 more common pathways
Pathways (97)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 27
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (74)
Find Similar Targets
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
1
2
61.4
birth weight
3
3
3
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
61.4
birth weight
3
59
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RB transcriptional corepressor 1
VGNC:14463
452715
Macaque
RB transcriptional corepressor 1
704871
Mouse
MGI:97874
19645
Rat
RGD:3540
24708
Dog
RB transcriptional corepressor 1
VGNC:45389
476915
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RB transcriptional corepressor 1
Macaque
RB transcriptional corepressor 1
Mouse
Rat
Dog
RB transcriptional corepressor 1
Publication Statistics
PubMed Score 1525.29
PubMed score by year
PubTator Score 3380.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title