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Tbio
RAVER1
Ribonucleoprotein PTB-binding 1

Protein Summary
Description
Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000615032
  • ENSP00000479520
  • ENSG00000161847

Symbol
  • KIAA1978
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
interacting protein
0.96
ligand (protein) perturbation
0.96
histone modification site profile
0.89
transcription factor binding site profile
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.21   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.21   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (87)
SCGN
Tbio
Novelty:  0.01434518
p_int:  0.999994446
p_ni:  0.000005554
Score:  0.171
Data Source:  BioPlex,STRINGDB
FKBP9
Tbio
Family:  Enzyme
Novelty:  0.16472204
p_int:  0.999988029
p_ni:  0.000011971
Score:  0.192
Data Source:  BioPlex,STRINGDB
CNOT3
Tbio
Novelty:  0.02463568
p_int:  0.999964303
p_ni:  0.000035697
Data Source:  BioPlex
CNOT11
Tbio
Novelty:  0.01687183
p_int:  0.999964021
p_ni:  0.000035979
Score:  0.808
Data Source:  BioPlex,STRINGDB
TOB1
Tbio
Novelty:  0.0163328
p_int:  0.99973189
p_ni:  0.000268109
p_wrong:  1e-9
Score:  0.74
Data Source:  BioPlex,STRINGDB
CNOT7
Tchem
Novelty:  0.04551853
p_int:  0.999207081
p_ni:  0.000792919
Score:  0.723
Data Source:  BioPlex,STRINGDB
CNOT10
Tdark
Novelty:  0.30195594
p_int:  0.997409277
p_ni:  0.00259072
p_wrong:  3e-9
Data Source:  BioPlex
FGL1
Tbio
Novelty:  0.02650803
p_int:  0.976725739
p_ni:  0.02327426
Data Source:  BioPlex
CDC16
Tbio
Novelty:  0.00916715
p_int:  0.958743162
p_ni:  0.041256838
Data Source:  BioPlex
GADD45B
Tbio
Novelty:  0.00611526
p_int:  0.95300993
p_ni:  0.04699007
Score:  0.747
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (41)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ICAM-1 measurement
2
3
0
13.8
97.6
IGF-1 measurement
1
4
4
96.7
reticulocyte count
7
7
13
95.2
6
5
0
1.2
92
myeloid white cell count
2
2
2
91.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ICAM-1 measurement
0
13.8
97.6
IGF-1 measurement
4
96.7
reticulocyte count
13
95.2
0
1.2
92
myeloid white cell count
2
91.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribonucleoprotein, PTB binding 1
VGNC:14753
101057136
Macaque
ribonucleoprotein, PTB binding 1
715250
Mouse
MGI:1919016
71766
Rat
RGD:1359190
298705
Dog
ribonucleoprotein, PTB binding 1
100683988
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribonucleoprotein, PTB binding 1
Macaque
ribonucleoprotein, PTB binding 1
Mouse
Rat
Dog
ribonucleoprotein, PTB binding 1
Publication Statistics
PubMed Score 13.21
PubMed score by year
PubTator Score 8.14
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title