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Tbio
RASSF8
Ras association domain-containing protein 8

Protein Summary
Description
This gene encodes a member of the Ras-assocation domain family (RASSF) of tumor suppressor proteins. This gene is essential for maintaining adherens junction function in epithelial cells and has a role in epithelial cell migration. It is a lung tumor suppressor gene candidate. A chromosomal translocation t(12;22)(p11.2;q13.3) leading to the fusion of this gene and the FBLN1 gene is found in a complex type of synpolydactyly. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282884
  • ENSP00000282884
  • ENSG00000123094
  • ENST00000381352
  • ENSP00000370756
  • ENST00000405154
  • ENSP00000384491
  • ENST00000541490
  • ENSP00000443096
  • ENST00000542865
  • ENSP00000439839
  • ENST00000615708
  • ENSP00000481417

Symbol
  • C12orf2
  • HOJ1
  • C12orf2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
microRNA
0.94
virus perturbation
0.79
transcription factor
0.69
small molecule perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.42   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 326   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.42   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 326   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
FRMD6
Tbio
Novelty:  0.0034642
p_int:  1
Score:  0.704
Data Source:  BioPlex,STRINGDB
PARD3
Tbio
Novelty:  0.00521327
p_int:  0.999999998
p_ni:  2e-9
Score:  0.828
Data Source:  BioPlex,STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
p_int:  0.999999958
p_ni:  4.2e-8
Score:  0.22
Data Source:  BioPlex,STRINGDB
TP53BP2
Tbio
Novelty:  0.01058379
p_int:  0.999999894
p_ni:  9.2e-8
p_wrong:  1.3e-8
Score:  0.921
Data Source:  BioPlex,STRINGDB
PPP1R13B
Tbio
Novelty:  0.03903985
p_int:  0.999999795
p_ni:  2.05e-7
Score:  0.852
Data Source:  BioPlex,STRINGDB
ZNF639
Tbio
Family:  TF
Novelty:  0.20063643
p_int:  0.999999548
p_ni:  4.5e-7
p_wrong:  2e-9
Score:  0.209
Data Source:  BioPlex,STRINGDB
ZBTB2
Tbio
Family:  TF
Novelty:  0.12299559
p_int:  0.999993256
p_ni:  0.000006744
p_wrong:  1e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.999986578
p_ni:  0.000013422
Score:  0.221
Data Source:  BioPlex,STRINGDB
POC1A
Tbio
Novelty:  0.03897985
p_int:  0.999877081
p_ni:  0.000122919
Data Source:  BioPlex
PCM1
Tbio
Novelty:  0.02901589
p_int:  0.999673395
p_ni:  0.000326605
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
4
4
81.1
waist-hip ratio
1
4
4
77.5
BMI-adjusted hip circumference
1
5
5
76.7
hip circumference
1
4
4
73
heel bone mineral density
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
4
81.1
waist-hip ratio
4
77.5
BMI-adjusted hip circumference
5
76.7
hip circumference
4
73
heel bone mineral density
1
47.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Ras association domain family member 8
VGNC:51262
466949
Macaque
Ras association domain family member 8
708284
Mouse
MGI:1918573
71323
Rat
RGD:1308820
312846
Dog
Ras association domain family member 8
VGNC:45385
477666
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Ras association domain family member 8
Macaque
Ras association domain family member 8
Mouse
Rat
Dog
Ras association domain family member 8
Publication Statistics
PubMed Score 16.42
PubMed score by year
PubTator Score 9.97
PubTator score by year
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Related Publications
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PMID
Year
Title