Tbio RASSF2 Ras association domain-containing protein 2

Protein Summary

Description

Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation. This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P50749
• A6NIX9
• A8K5Z3
• Q17S06
• Q53HD0
• Q6AHZ2
• Q8IZA5

Gene Name

• RASSF2

Ensembl ID

• ENST00000379376
• ENSP00000368684
• ENSG00000101265
• ENST00000379400
• ENSP00000368710

Symbol

• CENP-34
• KIAA0168
• CENP-34
• RASFADIN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.89
drug perturbation	0.87
microRNA	0.8
tissue sample	0.68
gene perturbation	0.62

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Ras Association Domain-containing Protein 2

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Ras Association Domain-containing Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.57   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 148   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.57   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0