Tbio RASSF1 Ras association domain-containing protein 1

Protein Summary

Description

Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage. This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, May 2011]

Uniprot Accession IDs

• Q9NS23
• B7ZLL1
• O14571
• O60539
• O60710
• Q0VGC6
• Q5TZT2
• Q9HB04
• Q9HB18
• Q9NS22
• Q9UND4
• Q9UND5

Gene Name

• RASSF1

Ensembl ID

• ENST00000327761
• ENSP00000333327
• ENSG00000068028
• ENST00000357043
• ENSP00000349547
• ENST00000359365
• ENSP00000352323
• ENST00000395117
• ENSP00000378549
• ENST00000395126
• ENSP00000378558
• ENST00000482447
• ENSP00000433000
• ENST00000616212
• ENSP00000482696

Symbol

• RDA32
• 123F2
• RDA32
• NORE2A
• RASSF1A
• REH3P21

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase	0.95
co-expressed gene	0.93
virus perturbation	0.88
biological term	0.86
hub protein	0.82

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Ras Association Domain-containing Protein 1

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Ras Association Domain-containing Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 858.24   (req: < 5)

Gene RIFs: 454   (req: <= 3)

Antibodies: 466   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 858.24   (req: >= 5)

Gene RIFs: 454   (req: > 3)

Antibodies: 466   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0