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Tbio
RASSF1
Ras association domain-containing protein 1

Protein Summary
Description
Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage. This gene encodes a protein si ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327761
  • ENSP00000333327
  • ENSG00000068028
  • ENST00000357043
  • ENSP00000349547
  • ENST00000359365
  • ENSP00000352323
  • ENST00000395117
  • ENSP00000378549
  • ENST00000395126
  • ENSP00000378558
  • ENST00000482447
  • ENSP00000433000
  • ENST00000616212
  • ENSP00000482696

Symbol
  • RDA32
  • 123F2
  • RDA32
  • NORE2A
  • RASSF1A
  • REH3P21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
0.95
co-expressed gene
0.93
virus perturbation
0.88
biological term
0.86
hub protein
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 858.24   (req: < 5)
Gene RIFs: 396   (req: <= 3)
Antibodies: 466   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 858.24   (req: >= 5)
Gene RIFs: 396   (req: > 3)
Antibodies: 466   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0