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Tbio
RASSF1
Ras association domain-containing protein 1

Protein Summary
Description
Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage. This gene encodes a protein si ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327761
  • ENSP00000333327
  • ENSG00000068028
  • ENST00000357043
  • ENSP00000349547
  • ENST00000359365
  • ENSP00000352323
  • ENST00000395117
  • ENSP00000378549
  • ENST00000395126
  • ENSP00000378558
  • ENST00000482447
  • ENSP00000433000
  • ENST00000616212
  • ENSP00000482696

Symbol
  • RDA32
  • 123F2
  • RDA32
  • NORE2A
  • RASSF1A
  • REH3P21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
0.95
co-expressed gene
0.93
virus perturbation
0.88
biological term
0.86
hub protein
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 816.89   (req: < 5)
Gene RIFs: 396   (req: <= 3)
Antibodies: 466   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 816.89   (req: >= 5)
Gene RIFs: 396   (req: > 3)
Antibodies: 466   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (164)
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.999999976
p_ni:  2e-8
p_wrong:  4e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.999999631
p_ni:  3.36e-7
p_wrong:  3.2e-8
Score:  0.252
Data Source:  BioPlex,STRINGDB
STK4
Tchem
Family:  Kinase
Novelty:  0.02104423
p_int:  0.999999112
p_ni:  8.88e-7
Score:  0.995
Data Source:  BioPlex,STRINGDB
STK3
Tchem
Family:  Kinase
Novelty:  0.0529257
p_int:  0.999998447
p_ni:  0.000001553
Score:  0.985
Data Source:  BioPlex,STRINGDB
BTRC
Tbio
Novelty:  0.00293475
p_int:  0.999998064
p_ni:  0.000001767
p_wrong:  1.68e-7
Score:  0.665
Data Source:  BioPlex,STRINGDB
MAP1S
Tbio
Novelty:  0.02643414
p_int:  0.999997782
p_ni:  0.000002218
Score:  0.829
Data Source:  BioPlex,STRINGDB
SNX27
Tbio
Novelty:  0.02419724
p_int:  0.999939846
p_ni:  0.000060154
Score:  0.306
Data Source:  BioPlex,STRINGDB
MTHFR
Tbio
Family:  Enzyme
Novelty:  0.00018162
p_int:  0.999918691
p_ni:  0.000081309
Score:  0.408
Data Source:  BioPlex,STRINGDB
MAP1B
Tchem
Novelty:  0.00215274
p_int:  0.999743557
p_ni:  0.000256443
p_wrong:  1e-9
Score:  0.493
Data Source:  BioPlex,STRINGDB
ITPRIP
Tdark
Novelty:  0.27051709
p_int:  0.995818444
p_ni:  0.004181556
Score:  0.228
Data Source:  BioPlex,STRINGDB
Pathways (77)
Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Non-small cell lung cancer
KEGG
Bladder cancer
KEGG
Hippo signaling pathway
KEGG
Hippo signaling pathway - multiple species
KEGG
Ras signaling pathway
Name
Explore in Pharos
Explore in Source
Non-small cell lung cancer
Bladder cancer
Hippo signaling pathway
Hippo signaling pathway - multiple species
Ras signaling pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
5
11
99.2
reticulocyte count
2
4
8
98.7
mean reticulocyte volume
1
1
1
85.1
chronotype measurement
1
2
0
1
78.7
macrophage inflammatory protein 1b measurement
1
2
2
66.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
11
99.2
reticulocyte count
8
98.7
mean reticulocyte volume
1
85.1
chronotype measurement
0
1
78.7
macrophage inflammatory protein 1b measurement
2
66.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
Ras association domain family member 1
702385
Mouse
MGI:1928386
56289
Rat
RGD:1359383
363140
Dog
Ras association domain family member 1
VGNC:45378
607929
Horse
Ras association domain family member 1
VGNC:52425
100061779
Species
Name
OMA
EggNOG
Inparanoid
Macaque
Ras association domain family member 1
Mouse
Rat
Dog
Ras association domain family member 1
Horse
Ras association domain family member 1
Publication Statistics
PubMed Score 816.89
PubMed score by year
PubTator Score 706.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title