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Tdark
RASL10B
Ras-like protein family member 10B

Protein Summary
Description
May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in the regulation of arterial pressure.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000603017
  • ENSP00000474230
  • ENSG00000270885

Symbol
  • RRP17
  • VTS58635
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.73
histone modification site profile
0.66
microRNA
0.56
PubMedID
0.49
gene perturbation
0.44


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.87   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.87   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
AHCYL2
Tbio
Family:  Enzyme
Novelty:  0.08695339
p_int:  0.999940794
p_ni:  0.000059206
Data Source:  BioPlex
MMADHC
Tbio
Novelty:  0.02299238
p_int:  0.999621138
p_ni:  0.000363736
p_wrong:  0.000015126
Score:  0.19
Data Source:  BioPlex,STRINGDB
FAM192A
Tdark
Novelty:  0.46220707
p_int:  0.999547746
p_ni:  0.000452254
Score:  0.239
Data Source:  BioPlex,STRINGDB
PSME3
Tbio
Novelty:  0.01051254
p_int:  0.999299969
p_ni:  0.000700031
Data Source:  BioPlex
AHCYL1
Tchem
Family:  Enzyme
Novelty:  0.02176432
p_int:  0.997118459
p_ni:  0.002881541
Data Source:  BioPlex
ZNF507
Tdark
Family:  TF
Novelty:  1.0899905
p_int:  0.995080352
p_ni:  0.004919648
Score:  0.25
Data Source:  BioPlex,STRINGDB
MAPK9
Tchem
Family:  Kinase
Novelty:  0.00267199
p_int:  0.995077748
p_ni:  0.004922251
p_wrong:  1e-9
Score:  0.255
Data Source:  BioPlex,STRINGDB
HSPD1
Tbio
Novelty:  0.00018924
p_int:  0.992871239
p_ni:  0.007128761
Score:  0.205
Data Source:  BioPlex,STRINGDB
PSMG3
Tchem
Novelty:  0.01730294
p_int:  0.985404939
p_ni:  0.014588766
p_wrong:  0.000006296
Data Source:  BioPlex
NDUFAF7
Tbio
Family:  Enzyme
Novelty:  0.24691414
p_int:  0.968313695
p_ni:  0.031573666
p_wrong:  0.000112638
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
3
3
94.2
reticulocyte count
5
3
5
92.4
macrophage inflammatory protein 1b measurement
1
2
2
82.9
mean reticulocyte volume
1
1
1
59.5
reticulocyte measurement
2
1
2
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
94.2
reticulocyte count
5
92.4
macrophage inflammatory protein 1b measurement
2
82.9
mean reticulocyte volume
1
59.5
reticulocyte measurement
2
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
RAS like family 10 member B
716171
Mouse
MGI:2685575
276952
Dog
RAS like family 10 member B
VGNC:45376
491138
Horse
RAS like family 10 member B
VGNC:22206
100058003
Cow
RAS like family 10 member B
VGNC:33753
522270
Species
Name
OMA
EggNOG
Inparanoid
Macaque
RAS like family 10 member B
Mouse
Dog
RAS like family 10 member B
Horse
RAS like family 10 member B
Cow
RAS like family 10 member B
Publication Statistics
PubMed Score 1.87
PubMed score by year
PubTator Score 3.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title