Tbio RASGRP4 RAS guanyl-releasing protein 4

Protein Summary

Description

Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation. The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

Uniprot Accession IDs

• Q8TDF6
• A6H8M4
• C0LTP2
• C0LTP3
• C0LTP4
• C0LTP5
• C0LTP7
• C9J416
• C9JHZ1
• Q8N858
• Q96QN5
• Q96QN6
• Q96QN7

Gene Name

• RASGRP4

Ensembl ID

• ENST00000293062
• ENSP00000293062
• ENSG00000171777
• ENST00000426920
• ENSP00000445966
• ENST00000433821
• ENSP00000411878
• ENST00000454404
• ENSP00000416463
• ENST00000586305
• ENSP00000467604
• ENST00000587738
• ENSP00000465772
• ENST00000587753
• ENSP00000468483
• ENST00000589358
• ENSP00000465742
• ENST00000589474
• ENSP00000466928
• ENST00000614135
• ENSP00000479078
• ENST00000615439
• ENSP00000479844
• ENST00000617966
• ENSP00000479888
• ENST00000622174
• ENSP00000484345

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
metabolite	0.82
tissue sample	0.74
cell type or tissue	0.64
trait	0.61

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Ras Guanyl-releasing Protein 4

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Ras Guanyl-releasing Protein 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.53   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 77   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.53   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0