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Tbio
RASGRP2
RAS guanyl-releasing protein 2

Protein Summary
Description
Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway. The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Four alternatively spliced transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354024
  • ENSP00000338864
  • ENSG00000068831
  • ENST00000377494
  • ENSP00000366714
  • ENST00000377497
  • ENSP00000366717
  • ENST00000394432
  • ENSP00000377953

Symbol
  • CDC25L
  • MCG7
  • CDC25L
  • CALDAG-GEFI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
protein domain
0.92
PubMedID
0.87
metabolite
0.82
transcription factor
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.63   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.63   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (78)
RAP1A
Tchem
Family:  Enzyme
Novelty:  0.00375413
Score:  0.983
Data Source:  Reactome,STRINGDB
RAP1B
Tbio
Family:  Enzyme
Novelty:  0.00627538
Score:  0.972
Data Source:  Reactome,STRINGDB
KRAS
Tclin
Family:  Enzyme
Novelty:  0.00013856
Score:  0.959
Data Source:  STRINGDB
NRAS
Tchem
Family:  Enzyme
Novelty:  0.00080922
Score:  0.954
Data Source:  STRINGDB
RRAS
Tbio
Family:  Enzyme
Novelty:  0.00786502
Score:  0.947
Data Source:  STRINGDB
ITPR1
Tchem
Family:  IC
Novelty:  0.00111834
Score:  0.909
Data Source:  STRINGDB
ITPR3
Tchem
Family:  IC
Novelty:  0.00154917
Score:  0.909
Data Source:  STRINGDB
RASGRP1
Tchem
Novelty:  0.00776879
Score:  0.908
Data Source:  STRINGDB
ITPR2
Tbio
Family:  IC
Novelty:  0.00619813
Score:  0.906
Data Source:  STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.782
Data Source:  STRINGDB
Nearest Tclin Targets (13)
Explore Nearest Tclin Targets
1 – 5 of 9
CACNA1S
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
CACNA1C
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
CACNA1G
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
CACNA2D2
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
CACNA1I
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
Pathways (440)
Adaptive Immune System (R-HSA-1280218)

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Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Effects of PIP2 hydrolysis
Reactome
FCERI mediated NF-kB activation
Reactome
Fc epsilon receptor (FCERI) signaling
Reactome
G alpha (q) signalling events
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Effects of PIP2 hydrolysis
FCERI mediated NF-kB activation
Fc epsilon receptor (FCERI) signaling
G alpha (q) signalling events
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
4
18
18
99.5
uric acid measurement
5
4
5
13.8
98.9
renal system measurement
1
1
1
85.7
3
2
0
1.4
50.6
body mass index
2
2
2
47.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
18
99.5
uric acid measurement
5
13.8
98.9
renal system measurement
1
85.7
0
1.4
50.6
body mass index
2
47.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAS guanyl releasing protein 2
VGNC:6695
451298
Macaque
RAS guanyl releasing protein 2
722044
Mouse
MGI:1333849
19395
Rat
RGD:1311630
361714
Dog
RAS guanyl releasing protein 2
VGNC:45372
612101
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAS guanyl releasing protein 2
Macaque
RAS guanyl releasing protein 2
Mouse
Rat
Dog
RAS guanyl releasing protein 2
Publication Statistics
PubMed Score 57.63
PubMed score by year
PubTator Score 21.15
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title