Tchem RASGRP1 RAS guanyl-releasing protein 1

Protein Summary

Description

Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994). Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (By similarity). May also function in differentiation of other cell types (PubMed:12845332). This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O95267
• Q56CZ0
• Q58G75
• Q59HB1
• Q5I3A8
• Q6GV31
• Q6NX39
• Q7LDG6
• Q9UI94
• Q9UNN9

Gene Name

• RASGRP1

Ensembl ID

• ENST00000310803
• ENSP00000310244
• ENSG00000172575
• ENST00000414708
• ENSP00000413105
• ENST00000450598
• ENSP00000388540
• ENST00000558164
• ENSP00000454164
• ENST00000559830
• ENSP00000452721

Symbol

• RASGRP
• RASGRP
• CALDAG-GEFI
• CALDAG-GEFII

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	1
protein domain	0.99
PubMedID	0.93
transcription factor perturbation	0.91
biological process	0.85

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Ras Guanyl-releasing Protein 1

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Ras Guanyl-releasing Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.8   (req: < 5)

Gene RIFs: 44   (req: <= 3)

Antibodies: 140   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.8   (req: >= 5)

Gene RIFs: 44   (req: > 3)

Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0