You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RASEF
Ras and EF-hand domain-containing protein

Protein Summary
Description
Binds predominantly GDP, and also GTP. This gene is a member of the Rab family of GTPases that are involved in regulation of membrane traffic. The encoded protein contains an N-terminal EF-hand domain, a coiled-coil motif and a C-terminal Rab domain. A potential role as tumor suppressor has been indicated for this gene. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340717
  • ENSP00000345651
  • ENSG00000165105
  • ENST00000376447
  • ENSP00000365630

Symbol
  • RAB45
  • RAB45
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
protein domain
0.92
gene perturbation
0.81
tissue sample
0.6
cell type or tissue
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.76   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.76   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
GDI1
Tbio
Novelty:  0.01710945
p_int:  0.999999466
p_ni:  7.3e-8
p_wrong:  4.61e-7
Score:  0.551
Data Source:  BioPlex,STRINGDB
UHRF1BP1
Tbio
Novelty:  0.1588079
p_int:  0.999999247
p_ni:  7.36e-7
p_wrong:  1.7e-8
Data Source:  BioPlex
RABL2B
Tdark
Family:  Enzyme
Novelty:  0.16730643
p_int:  0.999998222
p_ni:  0.00000162
p_wrong:  1.58e-7
Score:  0.705
Data Source:  BioPlex,STRINGDB
CHML
Tbio
Family:  Enzyme
Novelty:  0.00509709
p_int:  0.999985773
p_ni:  0.000014089
p_wrong:  1.37e-7
Score:  0.352
Data Source:  BioPlex,STRINGDB
FAM9C
Tdark
Novelty:  0.86727989
p_int:  0.999983721
p_ni:  0.000016277
p_wrong:  2e-9
Data Source:  BioPlex
CHM
Tbio
Family:  Enzyme
Novelty:  0.00226278
p_int:  0.999939728
p_ni:  0.00006027
p_wrong:  2e-9
Score:  0.337
Data Source:  BioPlex,STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
p_int:  0.999576873
p_ni:  0.000423127
Data Source:  BioPlex
ITPR2
Tbio
Family:  IC
Novelty:  0.00619813
p_int:  0.999473021
p_ni:  0.000526979
Data Source:  BioPlex
UHRF1BP1L
Tbio
Novelty:  0.55650495
p_int:  0.998862263
p_ni:  0.001137736
p_wrong:  1e-9
Data Source:  BioPlex
DYNC1LI2
Tbio
Novelty:  0.17381295
p_int:  0.998383363
p_ni:  0.001616637
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sleep measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sleep measurement
1
21.5
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAS and EF-hand domain containing
VGNC:13951
464548
Mouse
MGI:2448565
242505
Rat
RGD:1306418
298138
Dog
RAS and EF-hand domain containing
VGNC:45366
484152
Horse
RAS and EF-hand domain containing
VGNC:22195
100055690
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAS and EF-hand domain containing
Mouse
Rat
Dog
RAS and EF-hand domain containing
Horse
RAS and EF-hand domain containing
Publication Statistics
PubMed Score 12.76
PubMed score by year
PubTator Score 4.52
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title