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Tbio
RASD2
GTP-binding protein Rhes

Protein Summary
Description
GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination. This gene belongs to the Ras superfamily of small GTPases and is enriched in the striatum. The encoded protein functions as an E3 ligase for attachment of small ubiquitin-like modifier (SUMO). This protein also binds to mutant huntingtin (mHtt), the protein mutated in Huntington disease (HD). Sumoylation of mHTT by this protein may cause degeneration of the striatum. The protein functions as an activator of mechanistic target of rapamycin 1 (mTOR1), which in turn plays a role in myelination, axon growth and regeneration. Reduced levels of mRNA expressed by this gene were found in HD patients. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216127
  • ENSP00000216127
  • ENSG00000100302

Symbol
  • TEM2
  • Rhes
  • TEM2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
hub protein
0.63
tissue
0.6
histone modification site profile
0.59
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 222.05   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 336   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 222.05   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 336   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
SLC4A7
Tbio
Family:  Transporter
Novelty:  0.011156
p_int:  0.999782151
p_ni:  0.000217846
p_wrong:  3e-9
Score:  0.209
Data Source:  BioPlex,STRINGDB
LRP6
Tbio
Novelty:  0.00305615
p_int:  0.999438072
p_ni:  0.000561928
Score:  0.209
Data Source:  BioPlex,STRINGDB
LRP5
Tbio
Novelty:  0.00089807
p_int:  0.89631245
p_ni:  0.103687527
p_wrong:  2.3e-8
Score:  0.196
Data Source:  BioPlex,STRINGDB
CD248
Tbio
Novelty:  0.00063383
Score:  0.92
Data Source:  STRINGDB
PLXDC1
Tbio
Novelty:  0.01025354
Score:  0.792
Data Source:  STRINGDB
HTT
Tchem
Novelty:  0.00034051
Score:  0.759
Data Source:  STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.711
Data Source:  STRINGDB
TOM1
Tbio
Novelty:  0.00725956
Score:  0.693
Data Source:  STRINGDB
OXA1L
Tbio
Novelty:  0.00235517
Score:  0.679
Data Source:  STRINGDB
IPO5
Tbio
Novelty:  0.00452607
Score:  0.674
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
2
3
60.4
triglyceride measurement
2
2
2
54.3
intelligence
1
1
1
6.5
high density lipoprotein cholesterol measurement
1
1
1
4.1
balding measurement
1
1
1
3.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
60.4
triglyceride measurement
2
54.3
intelligence
1
6.5
high density lipoprotein cholesterol measurement
1
4.1
balding measurement
1
3.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RASD family member 2
VGNC:6018
470196
Mouse
MGI:1922391
75141
Rat
RGD:628594
171099
Dog
RASD family member 2
VGNC:45365
481284
Horse
RASD family member 2
VGNC:22194
100054386
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RASD family member 2
Mouse
Rat
Dog
RASD family member 2
Horse
RASD family member 2
Publication Statistics
PubMed Score 222.05
PubMed score by year
PubTator Score 58.69
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title