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Tbio
RASAL2
Ras GTPase-activating protein nGAP

Protein Summary
Description
Inhibitory regulator of the Ras-cyclic AMP pathway. This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367649
  • ENSP00000356621
  • ENSG00000075391
  • ENST00000462775
  • ENSP00000420558

Symbol
  • NGAP
  • NGAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.97
microRNA
0.91
transcription factor binding site profile
0.86
protein domain
0.85
small molecule perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.64   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.64   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
SHC1
Tchem
Novelty:  0.00083615
p_int:  0.999993855
p_ni:  0.000006103
p_wrong:  4.1e-8
Score:  0.311
Data Source:  BioPlex,STRINGDB
CSNK1A1
Tchem
Family:  Kinase
Novelty:  0.00636472
p_int:  0.999923365
p_ni:  0.000005614
p_wrong:  0.000071021
Score:  0.532
Data Source:  BioPlex,STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.93
Data Source:  STRINGDB
NF1
Tbio
Novelty:  0.00019092
Score:  0.929
Data Source:  STRINGDB
NRAS
Tchem
Family:  Enzyme
Novelty:  0.00080922
Score:  0.927
Data Source:  STRINGDB
RASA2
Tdark
Family:  Enzyme
Novelty:  0.06658896
Score:  0.925
Data Source:  STRINGDB
RASAL1
Tbio
Novelty:  0.02163608
Score:  0.925
Data Source:  STRINGDB
RASA3
Tbio
Family:  Enzyme
Novelty:  0.03196973
Score:  0.924
Data Source:  STRINGDB
RASA1
Tbio
Family:  Enzyme
Novelty:  0.00425286
Score:  0.924
Data Source:  STRINGDB
KRAS
Tclin
Family:  Enzyme
Novelty:  0.00013856
Score:  0.923
Data Source:  STRINGDB
Pathways (22)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FLT3 Signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
FLT3 Signaling
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
6
3
10
87
red blood cell distribution width
2
2
2
67.3
apolipoprotein A 1 measurement
1
1
1
63.1
platelet crit
1
1
1
50.6
triglyceride measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
10
87
red blood cell distribution width
2
67.3
apolipoprotein A 1 measurement
1
63.1
platelet crit
1
50.6
triglyceride measurement
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAS protein activator like 2
VGNC:1482
457547
Macaque
RAS protein activator like 2
718958
Mouse
MGI:2443881
226525
Rat
RGD:1307566
304893
Dog
RAS protein activator like 2
VGNC:45362
480056
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAS protein activator like 2
Macaque
RAS protein activator like 2
Mouse
Rat
Dog
RAS protein activator like 2
Publication Statistics
PubMed Score 34.64
PubMed score by year
PubTator Score 22.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title