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Tbio
RASAL1
RasGAP-activating-like protein 1

Protein Summary
Description
Probable inhibitory regulator of the Ras-cyclic AMP pathway (PubMed:9751798). Plays a role in dendrite formation by melanocytes (PubMed:23999003). The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261729
  • ENSP00000261729
  • ENSG00000111344
  • ENST00000446861
  • ENSP00000395920
  • ENST00000546530
  • ENSP00000450244
  • ENST00000548055
  • ENSP00000448510

Symbol
  • RASAL
  • RASAL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
kinase perturbation
0.81
disease perturbation
0.79
transcription factor
0.74
cell type or tissue
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.62   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.62   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.938
Data Source:  STRINGDB
KRAS
Tclin
Family:  Enzyme
Novelty:  0.00013856
Score:  0.936
Data Source:  STRINGDB
NRAS
Tchem
Family:  Enzyme
Novelty:  0.00080922
Score:  0.928
Data Source:  STRINGDB
SYNGAP1
Tbio
Family:  Enzyme
Novelty:  0.00570434
Score:  0.925
Data Source:  STRINGDB
RASAL2
Tbio
Family:  Enzyme
Novelty:  0.03671142
Score:  0.925
Data Source:  STRINGDB
RASA1
Tbio
Family:  Enzyme
Novelty:  0.00425286
Score:  0.924
Data Source:  STRINGDB
RASAL3
Tbio
Novelty:  0.22098972
Score:  0.923
Data Source:  STRINGDB
DAB2IP
Tchem
Novelty:  0.01423445
Score:  0.922
Data Source:  STRINGDB
NF1
Tbio
Novelty:  0.00019092
Score:  0.918
Data Source:  STRINGDB
RASA2
Tdark
Family:  Enzyme
Novelty:  0.06658896
Score:  0.915
Data Source:  STRINGDB
Pathways (61)
Cytokine Signaling in Immune system (R-HSA-1280215)

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Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FLT3 Signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
FLT3 Signaling
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to fenofibrate
1
1
1
36.9
BMI-adjusted waist-hip ratio
2
1
2
25.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to fenofibrate
1
36.9
BMI-adjusted waist-hip ratio
2
25.8
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAS protein activator like 1
VGNC:8519
452269
Macaque
RAS protein activator like 1
714353
Mouse
MGI:1330842
19415
Rat
RGD:1311820
360814
Dog
RAS protein activator like 1
VGNC:52961
486277
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAS protein activator like 1
Macaque
RAS protein activator like 1
Mouse
Rat
Dog
RAS protein activator like 1
Publication Statistics
PubMed Score 61.62
PubMed score by year
PubTator Score 26.60
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title