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Tbio
RASA3
Ras GTPase-activating protein 3

Protein Summary
Description
Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor. This gene encodes a protein that binds inositol 1,3,4,5-tetrakisphosphate and stimulates the GTPase activity of Ras p21. This protein functions as a negative regulator of the Ras signalling pathway. It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334062
  • ENSP00000335029
  • ENSG00000185989
  • ENST00000630618
  • ENSP00000486064
  • ENSG00000280477

Symbol
  • GAPIII
  • GAP1IP4BP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
protein domain
0.92
transcription factor perturbation
0.88
disease perturbation
0.87
cell type or tissue
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.57   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 263   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.57   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 263   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
NRAS
Tchem
Family:  Enzyme
Novelty:  0.00080922
Score:  0.947
Data Source:  STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.946
Data Source:  STRINGDB
KRAS
Tclin
Family:  Enzyme
Novelty:  0.00013856
Score:  0.94
Data Source:  STRINGDB
RASA1
Tbio
Family:  Enzyme
Novelty:  0.00425286
Score:  0.929
Data Source:  STRINGDB
RASAL3
Tbio
Novelty:  0.22098972
Score:  0.928
Data Source:  STRINGDB
SYNGAP1
Tbio
Family:  Enzyme
Novelty:  0.00570434
Score:  0.928
Data Source:  STRINGDB
RASAL2
Tbio
Family:  Enzyme
Novelty:  0.03671142
Score:  0.924
Data Source:  STRINGDB
DAB2IP
Tchem
Novelty:  0.01423445
Score:  0.921
Data Source:  STRINGDB
NF1
Tbio
Novelty:  0.00019092
Score:  0.918
Data Source:  STRINGDB
RASA4
Tbio
Family:  Enzyme
Novelty:  0.07418055
Score:  0.916
Data Source:  STRINGDB
Pathways (272)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FLT3 Signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
FLT3 Signaling
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (34)
Items per page:
1 – 5 of 34
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
4
7
8
90.9
lymphocyte count
4
7
8
90.9
lymphocyte percentage of leukocytes
1
3
3
81.9
lymphocyte percentage of leukocytes
1
3
3
81.9
triglyceride measurement
4
4
4
78.9
Items per page:
1 – 5 of 34
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
8
90.9
lymphocyte count
8
90.9
lymphocyte percentage of leukocytes
3
81.9
lymphocyte percentage of leukocytes
3
81.9
triglyceride measurement
4
78.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAS p21 protein activator 3
VGNC:14788
452684
Macaque
RAS p21 protein activator 3
698964
Mouse
MGI:1197013
19414
Rat
RGD:69365
29372
Dog
RAS p21 protein activator 3
VGNC:45361
476998
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAS p21 protein activator 3
Macaque
RAS p21 protein activator 3
Mouse
Rat
Dog
RAS p21 protein activator 3
Publication Statistics
PubMed Score 84.57
PubMed score by year
PubTator Score 23.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title