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Tdark
RASA2
Ras GTPase-activating protein 2

Protein Summary
Description
Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4). The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286364
  • ENSP00000286364
  • ENSG00000155903

Symbol
  • GAP1M
  • RASGAP
  • GAP1M
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
cell type or tissue
0.78
histone modification site profile
0.74
transcription factor perturbation
0.74
transcription factor binding site profile
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.79   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 40   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.79   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 40   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
HDGFL2
Tbio
Family:  Epigenetic
Novelty:  0.11846257
p_int:  0.998749292
p_ni:  0.000009514
p_wrong:  0.001241194
Data Source:  BioPlex
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.972
Data Source:  STRINGDB
NRAS
Tchem
Family:  Enzyme
Novelty:  0.00080922
Score:  0.955
Data Source:  STRINGDB
KRAS
Tclin
Family:  Enzyme
Novelty:  0.00013856
Score:  0.95
Data Source:  STRINGDB
RRAS
Tbio
Family:  Enzyme
Novelty:  0.00786502
Score:  0.948
Data Source:  STRINGDB
SPRED1
Tbio
Novelty:  0.01050285
Score:  0.937
Data Source:  STRINGDB
RASA1
Tbio
Family:  Enzyme
Novelty:  0.00425286
Score:  0.933
Data Source:  STRINGDB
NF1
Tbio
Novelty:  0.00019092
Score:  0.928
Data Source:  STRINGDB
SYNGAP1
Tbio
Family:  Enzyme
Novelty:  0.00570434
Score:  0.927
Data Source:  STRINGDB
RASAL2
Tbio
Family:  Enzyme
Novelty:  0.03671142
Score:  0.925
Data Source:  STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
1 – 4 of 4
PIK3CD
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  2
PIK3CA
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  2
RAF1
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  2
BRAF
Tclin
Family:  Kinase
KEGG Distance:  2
Common Pathways:  1
Pathways (28)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FLT3 Signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
FLT3 Signaling
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (60)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
8
6
8
99
BMI-adjusted hip circumference
2
11
12
98.7
BMI-adjusted waist circumference
7
8
20
92.1
body mass index
12
4
16
91.7
monocyte percentage of leukocytes
2
2
2
91.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
8
99
BMI-adjusted hip circumference
12
98.7
BMI-adjusted waist circumference
20
92.1
body mass index
16
91.7
monocyte percentage of leukocytes
2
91.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAS p21 protein activator 2
VGNC:7112
460741
Macaque
RAS p21 protein activator 2
715074
Mouse
MGI:2149960
114713
Rat
RGD:3538
25597
Dog
RAS p21 protein activator 2
VGNC:45360
485692
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAS p21 protein activator 2
Macaque
RAS p21 protein activator 2
Mouse
Rat
Dog
RAS p21 protein activator 2
Publication Statistics
PubMed Score 14.79
PubMed score by year
PubTator Score 14.86
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title