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Tbio
RARS2
Probable arginine--tRNA ligase, mitochondrial

Protein Summary
Description
This nuclear gene encodes a protein that localizes to the mitochondria, where it catalyzes the transfer of L-arginine to its cognate tRNA, an important step in translation of mitochondrially-encoded proteins. Defects in this gene are a cause of pontocerebellar hypoplasia type 6 (PCH6). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369536
  • ENSP00000358549
  • ENSG00000146282

Symbol
  • RARSL
  • PCH6
  • ArgRS
  • RARSL
  • DALRD2
  • PRO1992
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
molecular function
0.93
kinase perturbation
0.91
histone modification site profile
0.88
protein domain
0.85


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.09   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.09   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (160)
GFM2
Tbio
Novelty:  0.02945848
p_int:  0.991584967
p_ni:  0.002053795
p_wrong:  0.006361238
Score:  0.475
Data Source:  BioPlex,STRINGDB
ATP12A
Tchem
Family:  Transporter
Novelty:  0.00008793
p_int:  0.959935066
p_ni:  0.040064899
p_wrong:  3.5e-8
Data Source:  BioPlex
PITRM1
Tchem
Family:  Enzyme
Novelty:  0.08067518
p_int:  0.937274512
p_ni:  0.062725488
Score:  0.326
Data Source:  BioPlex,STRINGDB
HSPD1
Tbio
Novelty:  0.00018924
p_int:  0.937079552
p_ni:  0.062920448
Score:  0.202
Data Source:  BioPlex,STRINGDB
IL13RA2
Tbio
Novelty:  0.03465642
p_int:  0.896301302
p_ni:  0.103698698
Data Source:  BioPlex
PDPR
Tbio
Family:  Enzyme
Novelty:  0.04223174
p_int:  0.888863077
p_ni:  0.111136923
Score:  0.245
Data Source:  BioPlex,STRINGDB
CPS1
Tclin
Family:  Enzyme
Novelty:  0.00917469
p_int:  0.860916827
p_ni:  0.139083173
Score:  0.385
Data Source:  BioPlex,STRINGDB
ARL8A
Tbio
Family:  Enzyme
Novelty:  0.12499089
p_int:  0.853488848
p_ni:  0.146473828
p_wrong:  0.000037324
Score:  0.187
Data Source:  BioPlex,STRINGDB
NPY2R
Tchem
Family:  GPCR
Novelty:  0.01177255
p_int:  0.85280529
p_ni:  0.14719471
Data Source:  BioPlex
PCCA
Tbio
Family:  Enzyme
Novelty:  0.00515417
p_int:  0.787335771
p_ni:  0.212663755
p_wrong:  4.74e-7
Score:  0.201
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial tRNA aminoacylation
Reactome
Translation
Reactome
tRNA Aminoacylation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial tRNA aminoacylation
Translation
tRNA Aminoacylation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
1
2
75.7
mathematical ability
2
2
2
69.6
self reported educational attainment
1
1
1
63.4
household income
1
1
1
29
waist circumference
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
75.7
mathematical ability
2
69.6
self reported educational attainment
1
63.4
household income
1
29
waist circumference
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arginyl-tRNA synthetase 2, mitochondrial
VGNC:11201
462875
Macaque
arginyl-tRNA synthetase 2, mitochondrial
699240
Mouse
MGI:1923596
109093
Rat
RGD:1305419
297969
Dog
arginyl-tRNA synthetase 2, mitochondrial
VGNC:45358
481911
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arginyl-tRNA synthetase 2, mitochondrial
Macaque
arginyl-tRNA synthetase 2, mitochondrial
Mouse
Rat
Dog
arginyl-tRNA synthetase 2, mitochondrial
Publication Statistics
PubMed Score 84.09
PubMed score by year
PubTator Score 25.69
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title