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Tchem
RARS
Arginine--tRNA ligase, cytoplasmic

Protein Summary
Description
Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis (PubMed:25288775). Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1 (PubMed:17443684). Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Arginyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231572
  • ENSP00000231572
  • ENSG00000113643

Symbol
  • HLD9
  • ArgRS
  • DALRD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
0.99
molecular function
0.98
disease perturbation
0.93
virus perturbation
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 972.13   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 972.13   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (199)
KARS
Tchem
Family:  Enzyme
Novelty:  0.00386511
p_int:  0.999994549
p_ni:  0.000005451
Score:  0.999
Data Source:  BioPlex,STRINGDB
AIMP1
Tbio
Family:  Enzyme
Novelty:  0.00743447
p_int:  0.999993409
p_ni:  0.000006591
Score:  0.999
Data Source:  BioPlex,STRINGDB
LARS
Tchem
Family:  Enzyme
Novelty:  0.00361711
p_int:  0.999986955
p_ni:  0.000013045
Score:  0.998
Data Source:  BioPlex,STRINGDB
QARS
Tchem
Family:  Enzyme
Novelty:  0.01684657
p_int:  0.999747247
p_ni:  0.000252753
Score:  0.999
Data Source:  BioPlex,STRINGDB
DARS
Tbio
Family:  Enzyme
Novelty:  0.01101888
p_int:  0.999528633
p_ni:  0.000471367
Score:  0.996
Data Source:  BioPlex,STRINGDB
SDCBP
Tchem
Novelty:  0.00242211
p_int:  0.999487762
p_ni:  0.000512238
Score:  0.821
Data Source:  BioPlex,STRINGDB
TARSL2
Tbio
Family:  Enzyme
Novelty:  0.02406282
p_int:  0.999395206
p_ni:  0.000604794
Score:  0.881
Data Source:  BioPlex,STRINGDB
EEF1E1
Tbio
Novelty:  0.06216577
p_int:  0.998485918
p_ni:  0.001514082
Score:  0.997
Data Source:  BioPlex,STRINGDB
IARS
Tchem
Family:  Enzyme
Novelty:  0.00539046
p_int:  0.998073941
p_ni:  0.001926059
Score:  0.998
Data Source:  BioPlex,STRINGDB
NECTIN2
Tbio
Novelty:  0.00910836
p_int:  0.994315315
p_ni:  0.005684685
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Cytosolic tRNA aminoacylation (R-HSA-379716)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic tRNA aminoacylation
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of proteins
Reactome
Selenoamino acid metabolism
Name
Explore in Pharos
Explore in Source
Cytosolic tRNA aminoacylation
Metabolism
Metabolism of amino acids and derivatives
Metabolism of proteins
Selenoamino acid metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
3
3
53.1
health study participation
1
1
1
43.8
body height
1
1
1
27.9
hemoglobin A1 measurement
1
1
1
12.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
3
53.1
health study participation
1
43.8
body height
1
27.9
hemoglobin A1 measurement
1
12.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arginyl-tRNA synthetase
VGNC:13576
462249
Macaque
arginyl-tRNA synthetase
698998
Mouse
MGI:1914297
104458
Rat
RGD:1309215
287191
Dog
arginyl-tRNA synthetase
VGNC:45357
609803
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arginyl-tRNA synthetase
Macaque
arginyl-tRNA synthetase
Mouse
Rat
Dog
arginyl-tRNA synthetase
Publication Statistics
PubMed Score 972.13
PubMed score by year
PubTator Score 178.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title