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Tbio
RARRES1
Retinoic acid receptor responder protein 1

Protein Summary
Description
Inhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle. This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000237696
  • ENSP00000237696
  • ENSG00000118849
  • ENST00000479756
  • ENSP00000418556

Symbol
  • PEIG1
  • TIG1
  • LXNL
  • TIG1
  • PERG-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.94
gene perturbation
0.76
histone modification site profile
0.74
kinase perturbation
0.66
small molecule perturbation
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.06   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 308   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.06   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 308   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
TPX2
Tbio
Novelty:  0.00435921
p_int:  0.999999959
p_ni:  4.1e-8
Data Source:  BioPlex
ZBTB10
Tbio
Family:  TF
Novelty:  0.05707286
p_int:  0.999998895
p_ni:  0.000001105
Data Source:  BioPlex
ITPKC
Tchem
Family:  Kinase
Novelty:  0.03063007
p_int:  0.999995479
p_ni:  0.000001514
p_wrong:  0.000003007
Data Source:  BioPlex
KHDRBS3
Tbio
Novelty:  0.00490069
p_int:  0.999994793
p_ni:  0.000005203
p_wrong:  4e-9
Data Source:  BioPlex
ZNF318
Tbio
Novelty:  0.03072403
p_int:  0.999982067
p_ni:  0.000017933
Data Source:  BioPlex
ZNF609
Tdark
Novelty:  0.06635612
p_int:  0.999975008
p_ni:  0.000024992
Data Source:  BioPlex
METAP2
Tchem
Family:  Enzyme
Novelty:  0.00570955
p_int:  0.999906182
p_ni:  0.000093818
p_wrong:  1e-9
Data Source:  BioPlex
WIZ
Tbio
Family:  TF
Novelty:  0.04458547
p_int:  0.999834238
p_ni:  0.00016576
p_wrong:  2e-9
Data Source:  BioPlex
EHMT2
Tchem
Family:  Epigenetic
Novelty:  0.00262578
p_int:  0.999822313
p_ni:  0.000177687
Data Source:  BioPlex
EHMT1
Tchem
Family:  Epigenetic
Novelty:  0.00821799
p_int:  0.999782516
p_ni:  0.000217484
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
1
1
0
1.1
47.7
systolic blood pressure
1
1
1
42.3
insomnia measurement
1
1
0
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
0
1.1
47.7
systolic blood pressure
1
42.3
insomnia measurement
0
1
21.5
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
retinoic acid receptor responder 1
VGNC:12166
741650
Macaque
retinoic acid receptor responder 1
703781
Mouse
MGI:1924461
109222
Rat
RGD:1309509
310486
Dog
retinoic acid receptor responder 1
VGNC:45354
612298
Species
Name
OMA
EggNOG
Inparanoid
Chimp
retinoic acid receptor responder 1
Macaque
retinoic acid receptor responder 1
Mouse
Rat
Dog
retinoic acid receptor responder 1
Publication Statistics
PubMed Score 29.06
PubMed score by year
PubTator Score 86.56
PubTator score by year
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Related Publications
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PMID
Year
Title