You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
RAPGEFL1
Rap guanine nucleotide exchange factor-like 1

Protein Summary
Description
Probable guanine nucleotide exchange factor (GEF).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264644
  • ENSP00000264644
  • ENSG00000108352
  • ENST00000456989
  • ENSP00000394530

Symbol
  • Link-GEFII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.6
histone modification site profile
0.59
small molecule perturbation
0.56
cell line
0.54
cell type or tissue
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.97   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.97   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (11)
KNDC1
Tdark
Novelty:  0.1459108
Score:  0.754
Data Source:  STRINGDB
RRAD
Tbio
Family:  Enzyme
Novelty:  0.0028913
Score:  0.649
Data Source:  STRINGDB
SIPA1
Tbio
Novelty:  0.03916566
Score:  0.551
Data Source:  STRINGDB
MAP6D1
Tdark
Novelty:  0.07326913
Score:  0.545
Data Source:  STRINGDB
RGL4
Tdark
Novelty:  0.29339149
Score:  0.522
Data Source:  STRINGDB
CORO6
Tdark
Novelty:  0.37416507
Score:  0.464
Data Source:  STRINGDB
REM2
Tbio
Family:  Enzyme
Novelty:  0.02331436
Score:  0.454
Data Source:  STRINGDB
VAT1L
Tdark
Family:  Enzyme
Novelty:  0.45114244
Score:  0.427
Data Source:  STRINGDB
CISD3
Tbio
Novelty:  0.10931756
Score:  0.416
Data Source:  STRINGDB
KIAA1522
Tdark
Novelty:  0.15028395
Score:  0.407
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
1
4
75.6
high density lipoprotein cholesterol measurement
2
2
2
69.6
1
1
0
1.1
59.5
mathematical ability
2
1
2
49.5
mitochondrial DNA measurement
1
1
1
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
75.6
high density lipoprotein cholesterol measurement
2
69.6
0
1.1
59.5
mathematical ability
2
49.5
mitochondrial DNA measurement
1
48.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rap guanine nucleotide exchange factor like 1
VGNC:9555
745896
Macaque
Rap guanine nucleotide exchange factor like 1
699843
Mouse
MGI:3611446
268480
Horse
Rap guanine nucleotide exchange factor like 1 [Source:HGNC Symbol;Acc:HGNC:17428]
Cow
Rap guanine nucleotide exchange factor like 1
VGNC:33727
618568
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rap guanine nucleotide exchange factor like 1
Macaque
Rap guanine nucleotide exchange factor like 1
Mouse
Horse
Rap guanine nucleotide exchange factor like 1 [Source:HGNC Symbol;Acc:HGNC:17428]
Cow
Rap guanine nucleotide exchange factor like 1
Publication Statistics
PubMed Score 0.97
PubMed score by year
PubTator Score 1.55
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title