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Tbio
RAPGEF5
Rap guanine nucleotide exchange factor 5

Protein Summary
Description
Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation. Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000401957
  • ENSP00000384044
  • ENSG00000136237
  • ENST00000620335
  • ENSP00000479340

Symbol
  • GFR
  • KIAA0277
  • MRGEF
  • GFR
  • REPAC
  • MR-GEF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
cell type or tissue
0.78
microRNA
0.77
protein domain
0.73
phenotype
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.58   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 224   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.58   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (77)
ANK3
Tbio
Novelty:  0.00429246
p_int:  0.999999985
p_ni:  1.5e-8
Score:  0.218
Data Source:  BioPlex,STRINGDB
ANK1
Tbio
Novelty:  0.00225305
p_int:  0.999999879
p_ni:  1.03e-7
p_wrong:  1.8e-8
Score:  0.259
Data Source:  BioPlex,STRINGDB
MAPK8IP2
Tbio
Family:  Enzyme
Novelty:  0.01788453
p_int:  0.99999654
p_ni:  0.000003289
p_wrong:  1.71e-7
Score:  0.227
Data Source:  BioPlex,STRINGDB
ANK2
Tbio
Novelty:  0.00528351
p_int:  0.999993677
p_ni:  0.000006321
p_wrong:  2e-9
Score:  0.269
Data Source:  BioPlex,STRINGDB
DDHD2
Tbio
Family:  Enzyme
Novelty:  0.04306798
p_int:  0.996616166
p_ni:  0.003380031
p_wrong:  0.000003803
Data Source:  BioPlex
TUBB1
Tclin
Novelty:  0.02806117
p_int:  0.994993135
p_ni:  0.005006865
Data Source:  BioPlex
HSP90AA4P
Tdark
p_int:  0.993248427
p_ni:  0.006751541
p_wrong:  3.2e-8
Data Source:  BioPlex
CCDC88A
Tbio
Novelty:  0.01077253
p_int:  0.990948434
p_ni:  0.009051566
Score:  0.156
Data Source:  BioPlex,STRINGDB
UBB
Tbio
Novelty:  0.00661254
p_int:  0.990917703
p_ni:  0.009082297
Data Source:  BioPlex
HERC1
Tbio
Family:  Enzyme
Novelty:  0.04318441
p_int:  0.989767664
p_ni:  0.010232336
Data Source:  BioPlex
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
1 – 3 of 3
CALM3
Tclin
Family:  Other
KEGG Distance:  3
Common Pathways:  2
CALM1
Tclin
Family:  Other
KEGG Distance:  3
Common Pathways:  2
CALM2
Tclin
Family:  Other
KEGG Distance:  3
Common Pathways:  2
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
17.2
albuminuria
1
1
0
36.9
7.8
1
1
0
1.1
0.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
17.2
albuminuria
0
36.9
7.8
0
1.1
0.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rap guanine nucleotide exchange factor 5
VGNC:4487
463284
Macaque
Rap guanine nucleotide exchange factor 5
711698
Mouse
MGI:2444365
217944
Rat
RGD:1561668
362799
Dog
Rap guanine nucleotide exchange factor 5
VGNC:45349
100855786
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rap guanine nucleotide exchange factor 5
Macaque
Rap guanine nucleotide exchange factor 5
Mouse
Rat
Dog
Rap guanine nucleotide exchange factor 5
Publication Statistics
PubMed Score 38.58
PubMed score by year
PubTator Score 293.11
PubTator score by year
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Related Publications
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PMID
Year
Title