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Tbio
RAP2C
Ras-related protein Rap-2c

Protein Summary
Description
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription. The protein encoded by this gene is a member of the Ras-related protein subfamily of the Ras GTPase superfamily. Members of this family are small GTPases that act as molecular switches to regulate cellular proliferation, differentiation, and apoptosis. This protein has been reported to activate in vitro transcriptional activity of the serum response element. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342983
  • ENSP00000340274
  • ENSG00000123728
  • ENST00000370874
  • ENSP00000359911
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
molecular function
0.86
kinase perturbation
0.84
microRNA
0.81
histone modification site profile
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.66   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.66   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (120)
MAP4K4
Tchem
Family:  Kinase
Novelty:  0.00702733
p_int:  0.999998062
p_ni:  0.000001938
Score:  0.291
Data Source:  BioPlex,STRINGDB
RAP1GDS1
Tbio
Family:  Enzyme
Novelty:  0.06140479
p_int:  0.997722479
p_ni:  0.002277521
Score:  0.485
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.988557223
p_ni:  0.011442777
Data Source:  BioPlex
CCT3
Tbio
Novelty:  0.01642521
p_int:  0.986505309
p_ni:  0.013494691
Score:  0.542
Data Source:  BioPlex,STRINGDB
CCT4
Tbio
Novelty:  0.01176123
p_int:  0.984055745
p_ni:  0.015944255
Score:  0.306
Data Source:  BioPlex,STRINGDB
TCP1
Tbio
Novelty:  0.00395241
p_int:  0.967135383
p_ni:  0.032864617
Score:  0.258
Data Source:  BioPlex,STRINGDB
CCT6A
Tbio
Novelty:  0.02368046
p_int:  0.936357986
p_ni:  0.063642014
Score:  0.419
Data Source:  BioPlex,STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
p_int:  0.93628291
p_ni:  0.063717089
p_wrong:  1e-9
Score:  0.327
Data Source:  BioPlex,STRINGDB
CCT7
Tbio
Novelty:  0.02247038
p_int:  0.893017965
p_ni:  0.106982035
Score:  0.542
Data Source:  BioPlex,STRINGDB
CCT6B
Tdark
Novelty:  0.28933315
p_int:  0.852728901
p_ni:  0.147271099
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Immune System (R-HSA-168256)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
40.7
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1919315
72065
Rat
RGD:1588562
302495
Dog
RAP2C, member of RAS oncogene family
VGNC:45345
481054
Horse
RAP2C, member of RAS oncogene family
VGNC:22178
100054364
Cow
RAP2C, member of RAS oncogene family
VGNC:33721
515181
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
RAP2C, member of RAS oncogene family
Horse
RAP2C, member of RAS oncogene family
Cow
RAP2C, member of RAS oncogene family
Publication Statistics
PubMed Score 15.66
PubMed score by year
PubTator Score 4.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title