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Tbio
RAP2A
Ras-related protein Rap-2a

Protein Summary
Description
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245304
  • ENSP00000245304
  • ENSG00000125249

Symbol
  • KREV
  • RAP2
  • K-REV
  • RbBP-30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
molecular function
0.91
transcription factor binding site profile
0.9
biological process
0.84
virus perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.56   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.56   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (104)
RABGGTB
Tbio
Family:  Enzyme
Novelty:  0.06786314
p_int:  0.993818531
p_ni:  0.006181469
Score:  0.263
Data Source:  BioPlex,STRINGDB
SDC1
Tbio
Novelty:  0.00044792
p_int:  0.981317274
p_ni:  0.018682726
Score:  0.181
Data Source:  BioPlex,STRINGDB
TMEM185A
Tdark
Novelty:  0.0262898
p_int:  0.976166976
p_ni:  0.023833024
Data Source:  BioPlex
CYP2S1
Tbio
Novelty:  0.02967417
p_int:  0.921455792
p_ni:  0.078543881
p_wrong:  3.27e-7
Score:  0.168
Data Source:  BioPlex,STRINGDB
MARVELD2
Tbio
Novelty:  0.01228406
p_int:  0.91484625
p_ni:  0.085153721
p_wrong:  2.8e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
S1PR1
Tclin
Family:  GPCR
Novelty:  0.00162513
p_int:  0.851972424
p_ni:  0.148025897
p_wrong:  0.000001678
Score:  0.181
Data Source:  BioPlex,STRINGDB
KIFAP3
Tbio
Novelty:  0.01902437
p_int:  0.797593071
p_ni:  0.202406639
p_wrong:  2.91e-7
Score:  0.175
Data Source:  BioPlex,STRINGDB
NCSTN
Tbio
Novelty:  0.00453935
p_int:  0.784875915
p_ni:  0.215124079
p_wrong:  6e-9
Score:  0.169
Data Source:  BioPlex,STRINGDB
VDAC3
Tbio
Novelty:  0.0095068
p_int:  0.751432182
p_ni:  0.248567266
p_wrong:  5.52e-7
Score:  0.222
Data Source:  BioPlex,STRINGDB
CXCL12
Tchem
Novelty:  0.00026817
Score:  0.915
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Integrin signalling pathway
PathwayCommons: pid
CXCR4-mediated signaling events
PathwayCommons: netpath
BCR
Name
Explore in Pharos
Explore in Source
Integrin signalling pathway
CXCR4-mediated signaling events
BCR
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
3
63
diastolic blood pressure
1
1
1
57.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
63
diastolic blood pressure
1
57.3
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAP2A, member of RAS oncogene family
VGNC:9814
452629
Mouse
MGI:97855
76108
Cow
RAP2A, member of RAS oncogene family
VGNC:33719
522707
Opossum
RAP2A, member of RAS oncogene family
100026652
Chicken
RAP2A, member of RAS oncogene family
CGNC:12674
769797
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAP2A, member of RAS oncogene family
Mouse
Cow
RAP2A, member of RAS oncogene family
Opossum
RAP2A, member of RAS oncogene family
Chicken
RAP2A, member of RAS oncogene family
Publication Statistics
PubMed Score 177.56
PubMed score by year
PubTator Score 74.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title