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Tbio
RAP1GDS1
Rap1 GTPase-GDP dissociation stimulator 1

Protein Summary
Description
Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein. The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993 [PubMed 8262526]).[supplied by OMIM, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264572
  • ENSP00000264572
  • ENSG00000138698
  • ENST00000339360
  • ENSP00000340454
  • ENST00000380158
  • ENSP00000369503
  • ENST00000408900
  • ENSP00000386223
  • ENST00000408927
  • ENSP00000386153
  • ENST00000453712
  • ENSP00000407157

Symbol
  • GDS1
  • SmgGDS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
kinase perturbation
0.93
transcription factor perturbation
0.91
histone modification site profile
0.9
interacting protein
0.86


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.04   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.04   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (102)
DIRAS1
Tbio
Family:  Enzyme
Novelty:  0.13332903
p_int:  0.999999921
p_ni:  7.6e-8
p_wrong:  3e-9
Score:  0.683
Data Source:  BioPlex,STRINGDB
UBTF
Tbio
Family:  TF
Novelty:  0.00421069
p_int:  0.999999877
p_ni:  1.23e-7
Data Source:  BioPlex
RAP1A
Tchem
Family:  Enzyme
Novelty:  0.00375413
p_int:  0.999999609
p_ni:  3.2e-7
p_wrong:  7e-8
Score:  0.596
Data Source:  BioPlex,STRINGDB
PLEKHB1
Tbio
Novelty:  0.0106759
p_int:  0.999998081
p_ni:  8.93e-7
p_wrong:  0.000001026
Score:  0.288
Data Source:  BioPlex,STRINGDB
DIRAS2
Tbio
Family:  Enzyme
Novelty:  0.12334631
p_int:  0.999995446
p_ni:  0.000004554
Score:  0.69
Data Source:  BioPlex,STRINGDB
RAC3
Tbio
Family:  Enzyme
Novelty:  0.02125361
p_int:  0.999944471
p_ni:  0.000049086
p_wrong:  0.000006443
Score:  0.748
Data Source:  BioPlex,STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
p_int:  0.999601735
p_ni:  0.000398265
Score:  0.966
Data Source:  BioPlex,STRINGDB
PRDM10
Tbio
Family:  TF; Epigenetic
Novelty:  0.03463517
p_int:  0.99941094
p_ni:  0.00058906
Data Source:  BioPlex
RAP2C
Tbio
Family:  Enzyme
Novelty:  0.08572837
p_int:  0.997722479
p_ni:  0.002277521
Score:  0.485
Data Source:  BioPlex,STRINGDB
RAP1B
Tbio
Family:  Enzyme
Novelty:  0.00627538
p_int:  0.99524063
p_ni:  0.00475937
Score:  0.604
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
Regulation of RAC1 activity
PathwayCommons: pid
Regulation of RhoA activity
Name
Explore in Pharos
Explore in Source
Regulation of RAC1 activity
Regulation of RhoA activity
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
1
1
1
58.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
1
58.5
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rap1 GTPase-GDP dissociation stimulator 1
VGNC:8270
461388
Macaque
Rap1 GTPase-GDP dissociation stimulator 1
706303
Mouse
MGI:2385189
229877
Rat
RGD:1308558
310909
Dog
Rap1 GTPase-GDP dissociation stimulator 1
VGNC:45343
487868
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rap1 GTPase-GDP dissociation stimulator 1
Macaque
Rap1 GTPase-GDP dissociation stimulator 1
Mouse
Rat
Dog
Rap1 GTPase-GDP dissociation stimulator 1
Publication Statistics
PubMed Score 31.04
PubMed score by year
PubTator Score 31.26
PubTator score by year
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Related Publications
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0 of 0
PMID
Text