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Tbio
RANGRF
Ran guanine nucleotide release factor

Protein Summary
Description
May regulate the intracellular trafficking of RAN (PubMed:11290418). Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed:29040603). Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (PubMed:29040603). Enhances the expression of SCN5A at the cell membrane in cardiomyocytes (PubMed:18184654, PubMed:23420830, PubMed:21621375). This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226105
  • ENSP00000226105
  • ENSG00000108961
  • ENST00000407006
  • ENSP00000383940
  • ENST00000439238
  • ENSP00000413190
  • ENST00000580434
  • ENSP00000462310

Symbol
  • MOG1
  • RANGNRF
  • MOG1
  • HSPC165
  • HSPC236
  • RANGNRF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
disease perturbation
0.74
kinase perturbation
0.66
tissue sample
0.65
gene perturbation
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.33   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 50   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.33   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
RAN
Tchem
Family:  Enzyme
Novelty:  0.00160888
p_int:  0.999998699
p_ni:  2.9e-8
p_wrong:  0.000001272
Score:  0.953
Data Source:  BioPlex,STRINGDB
LRRC56
Tdark
Novelty:  1.32360532
p_int:  0.99999444
p_ni:  0.000004925
p_wrong:  6.35e-7
Score:  0.199
Data Source:  BioPlex,STRINGDB
SGCZ
Tbio
Novelty:  0.08511312
p_int:  0.999992685
p_ni:  0.00000607
p_wrong:  0.000001245
Score:  0.169
Data Source:  BioPlex,STRINGDB
TSEN15
Tbio
Family:  Enzyme
Novelty:  0.17606559
p_int:  0.999642205
p_ni:  0.000308197
p_wrong:  0.000049598
Score:  0.189
Data Source:  BioPlex,STRINGDB
SRSF2
Tbio
Novelty:  0.00207072
p_int:  0.999576677
p_ni:  0.000397779
p_wrong:  0.000025543
Data Source:  BioPlex
RAB30
Tbio
Family:  Enzyme
Novelty:  0.1262404
p_int:  0.999501882
p_ni:  0.00044823
p_wrong:  0.000049887
Data Source:  BioPlex
SAPCD1
Tdark
Novelty:  0.90892824
p_int:  0.999431628
p_ni:  0.000335327
p_wrong:  0.000233045
Score:  0.234
Data Source:  BioPlex,STRINGDB
RAB3A
Tbio
Family:  Enzyme
Novelty:  0.0043532
p_int:  0.993727833
p_ni:  0.00130058
p_wrong:  0.004971587
Data Source:  BioPlex
GNG2
Tbio
Novelty:  0.04807242
p_int:  0.99107854
p_ni:  0.00721538
p_wrong:  0.00170608
Data Source:  BioPlex
IGSF6
Tbio
Novelty:  0.05015035
p_int:  0.981363371
p_ni:  0.001728712
p_wrong:  0.016907916
Score:  0.188
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Phase 0 - rapid depolarisation
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Phase 0 - rapid depolarisation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
3
4
94.2
hemoglobin measurement
2
2
2
84.7
total cholesterol measurement
2
2
2
77.4
mean corpuscular volume
1
1
1
72.9
reticulocyte measurement
1
2
2
69.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
4
94.2
hemoglobin measurement
2
84.7
total cholesterol measurement
2
77.4
mean corpuscular volume
1
72.9
reticulocyte measurement
2
69.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAN guanine nucleotide release factor
VGNC:9554
100608681
Macaque
RAN guanine nucleotide release factor
717206
Rat
RGD:1563195
287419
Dog
RAN guanine nucleotide release factor
VGNC:45341
479494
Horse
RAN guanine nucleotide release factor
VGNC:22176
100062561
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAN guanine nucleotide release factor
Macaque
RAN guanine nucleotide release factor
Rat
Dog
RAN guanine nucleotide release factor
Horse
RAN guanine nucleotide release factor
Publication Statistics
PubMed Score 34.33
PubMed score by year
PubTator Score 13.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title