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Tbio
RANGAP1
Ran GTPase-activating protein 1

Protein Summary
Description
GTPase activator for RAN (PubMed:8146159, PubMed:8896452, PubMed:16428860). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:8896452, PubMed:27160050). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050). This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356244
  • ENSP00000348577
  • ENSG00000100401
  • ENST00000405486
  • ENSP00000385866
  • ENST00000455915
  • ENSP00000401470

Symbol
  • KIAA1835
  • SD
  • SD
  • Fug1
  • RANGAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein complex
1
transcription factor binding site profile
0.91
hub protein
0.88
transcription factor perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.2   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 349   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.2   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 349   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (295)
RAN
Tchem
Family:  Enzyme
Novelty:  0.00160888
p_int:  0.99877749
p_ni:  0.00122251
Score:  0.999
Data Source:  BioPlex,STRINGDB
B2M
Tbio
Novelty:  0.00011248
p_int:  0.99862759
p_ni:  0.00137241
Score:  0.827
Data Source:  BioPlex,STRINGDB
RCC1
Tbio
Novelty:  0.00260884
p_int:  0.998526406
p_ni:  0.001473594
Score:  0.997
Data Source:  BioPlex,STRINGDB
UBE2I
Tbio
Novelty:  0.00267883
p_int:  0.996455403
p_ni:  0.003544597
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
NEMP1
Tdark
Novelty:  0.37603456
p_int:  0.988951893
p_ni:  0.011048107
Score:  0.873
Data Source:  BioPlex,STRINGDB
RANBP2
Tbio
Family:  Enzyme
Novelty:  0.00484823
Score:  0.999
Data Source:  Reactome,STRINGDB
SUMO1
Tbio
Novelty:  0.00137629
Score:  0.998
Data Source:  Reactome,STRINGDB
XPO1
Tclin
Novelty:  0.00078187
Score:  0.997
Data Source:  STRINGDB
SUMO2
Tbio
Novelty:  0.00366833
Score:  0.997
Data Source:  STRINGDB
RANBP1
Tbio
Family:  Enzyme
Novelty:  0.01208948
Score:  0.996
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (33)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

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Find Similar Targets
Items per page:
1 – 5 of 29
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
FlyBase
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (44)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
3
2
1
94.8
mathematical ability
2
2
3
90.6
neuroticism measurement
7
8
5
7.3
89.9
1
2
0
5.9
88.5
eosinophil percentage of leukocytes
2
2
2
85.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
94.8
mathematical ability
3
90.6
neuroticism measurement
5
7.3
89.9
0
5.9
88.5
eosinophil percentage of leukocytes
2
85.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Ran GTPase activating protein 1
VGNC:6017
458980
Macaque
Ran GTPase activating protein 1
710698
Mouse
MGI:103071
19387
Rat
RGD:1310380
362965
Dog
Ran GTPase activating protein 1
VGNC:45340
481234
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Ran GTPase activating protein 1
Macaque
Ran GTPase activating protein 1
Mouse
Rat
Dog
Ran GTPase activating protein 1
Publication Statistics
PubMed Score 99.20
PubMed score by year
PubTator Score 61.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title