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Tdark
RANBP6
Ran-binding protein 6

Protein Summary
Description
May function in nuclear protein import as nuclear transport receptor.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259569
  • ENSP00000259569
  • ENSG00000137040
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.85
histone modification site profile
0.73
transcription factor binding site profile
0.67
cell type or tissue
0.63
cell line
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.01   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.01   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (130)
ATP9A
Tbio
Family:  Transporter
Novelty:  0.15755352
p_int:  0.999999391
p_ni:  6.08e-7
Data Source:  BioPlex
MRPL34
Tdark
Novelty:  1.17388411
p_int:  0.999987516
p_ni:  0.000012484
Data Source:  BioPlex
STEAP3
Tbio
Family:  Enzyme
Novelty:  0.02042104
p_int:  0.999958589
p_ni:  0.000041408
p_wrong:  4e-9
Data Source:  BioPlex
ATP2B3
Tbio
Family:  Transporter
Novelty:  0.00901493
p_int:  0.99978019
p_ni:  0.00021981
Score:  0.164
Data Source:  BioPlex,STRINGDB
SLC27A2
Tbio
Family:  Transporter
Novelty:  0.01436035
p_int:  0.999706887
p_ni:  0.000293113
Data Source:  BioPlex
C3orf33
Tbio
Novelty:  0.29931973
p_int:  0.999654147
p_ni:  0.000345811
p_wrong:  4.2e-8
Data Source:  BioPlex
RPL37
Tbio
Novelty:  0.03935854
p_int:  0.997580722
p_ni:  0.002419278
Data Source:  BioPlex
TNFSF13B
Tclin
Novelty:  0.00069885
p_int:  0.997559371
p_ni:  0.002440629
Data Source:  BioPlex
EXOG
Tbio
Family:  Enzyme
Novelty:  0.03588463
p_int:  0.996846851
p_ni:  0.003153133
p_wrong:  1.6e-8
Score:  0.193
Data Source:  BioPlex,STRINGDB
TYW1B
Tdark
Family:  Enzyme
Novelty:  0.86504466
p_int:  0.995902228
p_ni:  0.004047112
p_wrong:  0.00005066
Score:  0.253
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
asthma
4
4
0
1.1
95.7
age at onset
1
2
0
1.1
70.1
glycine measurement
3
1
3
58.5
appendicular lean mass
1
1
1
43.2
childhood onset asthma
1
1
0
1.2
40.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
asthma
0
1.1
95.7
age at onset
0
1.1
70.1
glycine measurement
3
58.5
appendicular lean mass
1
43.2
childhood onset asthma
0
1.2
40.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2683212
240614
Rat
RGD:1305165
309326
Horse
RAN binding protein 6
VGNC:22173
100059812
Cow
RAN binding protein 6
VGNC:50254
526705
C. elegans
3565440
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
RAN binding protein 6
Cow
RAN binding protein 6
C. elegans
Publication Statistics
PubMed Score 1.01
PubMed score by year
PubTator Score 1.88
PubTator score by year
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Related Publications
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PMID
Year
Title