Tbio RANBP3 Ran-binding protein 3

Protein Summary

Description

Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9H6Z4
• B2RAT8
• O60405
• O75759
• O75760
• Q9BT47
• Q9UG74
• RanBP3

Gene Name

• RANBP3

Ensembl ID

• ENST00000034275
• ENSP00000034275
• ENSG00000031823
• ENST00000340578
• ENSP00000341483
• ENST00000439268
• ENSP00000404837

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
ligand (protein) perturbation	0.83
transcription factor binding site profile	0.74
drug perturbation	0.71
tissue sample	0.7

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Ran-binding Protein 3

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Ran-binding Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.68   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 229   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.68   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0