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Tbio
RALGAPB
Ral GTPase-activating protein subunit beta

Protein Summary
Description
Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262879
  • ENSP00000262879
  • ENSG00000170471
  • ENST00000397040
  • ENSP00000380233
  • ENST00000397042
  • ENSP00000380235

Symbol
  • KIAA1219
  • KIAA1219
  • RalGAPbeta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.95
microRNA
0.82
kinase perturbation
0.81
histone modification site profile
0.74
transcription factor binding site profile
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.97   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 22   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.97   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 22   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
NKIRAS2
Tbio
Family:  Enzyme
Novelty:  0.11182522
p_int:  0.999999992
p_ni:  8e-9
Score:  0.697
Data Source:  BioPlex,STRINGDB
GFOD1
Tdark
Family:  Enzyme
Novelty:  0.35031766
p_int:  0.999999972
p_ni:  2.8e-8
Score:  0.534
Data Source:  BioPlex,STRINGDB
DLG3
Tbio
Novelty:  0.01196565
p_int:  0.999997992
p_ni:  0.000002008
Data Source:  BioPlex
DPH7
Tbio
Family:  Enzyme
Novelty:  0.05925085
p_int:  0.999343213
p_ni:  0.000656782
p_wrong:  5e-9
Score:  0.19
Data Source:  BioPlex,STRINGDB
C12orf74
Tdark
Novelty:  2.54545455
p_int:  0.993531656
p_ni:  0.006468344
Score:  0.209
Data Source:  BioPlex,STRINGDB
DND1
Tbio
Novelty:  0.0287312
p_int:  0.989706682
p_ni:  0.010293314
p_wrong:  4e-9
Score:  0.261
Data Source:  BioPlex,STRINGDB
SERPINB2
Tbio
Novelty:  0.00204345
p_int:  0.989411118
p_ni:  0.010588879
p_wrong:  3e-9
Data Source:  BioPlex
LINC01587
Tdark
Novelty:  0.48128342
p_int:  0.985316921
p_ni:  0.014683076
p_wrong:  3e-9
Score:  0.175
Data Source:  BioPlex,STRINGDB
IRGM
Tbio
Family:  Enzyme
Novelty:  0.0065731
p_int:  0.982519234
p_ni:  0.017480762
p_wrong:  4e-9
Data Source:  BioPlex
BTRC
Tbio
Novelty:  0.00293475
p_int:  0.978435343
p_ni:  0.007411566
p_wrong:  0.014153091
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
excessive daytime sleepiness measurement
1
1
1
5.8
body mass index
1
1
1
5.2
insulin sensitivity measurement
1
1
1
5.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
excessive daytime sleepiness measurement
1
5.8
body mass index
1
5.2
insulin sensitivity measurement
1
5.2
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Ral GTPase activating protein non-catalytic beta subunit
VGNC:9958
458242
Macaque
Ral GTPase activating protein non-catalytic beta subunit
705742
Mouse
MGI:2444531
228850
Rat
RGD:1306861
362257
Dog
Ral GTPase activating protein non-catalytic beta subunit
VGNC:45334
612869
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Ral GTPase activating protein non-catalytic beta subunit
Macaque
Ral GTPase activating protein non-catalytic beta subunit
Mouse
Rat
Dog
Ral GTPase activating protein non-catalytic beta subunit
Publication Statistics
PubMed Score 2.97
PubMed score by year
PubTator Score 1.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title