Tbio RALGAPA2 Ral GTPase-activating protein subunit alpha-2

Protein Summary

Description

Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB.

Uniprot Accession IDs

• Q2PPJ7
• Q4VXU6
• Q5JUA3
• Q5JUA4
• Q5T9K3
• Q96CX9
• Q9BQT7
• Q9H9D9
• Q9ULE8

Gene Name

• RALGAPA2

Ensembl ID

• ENST00000202677
• ENSP00000202677
• ENSG00000188559

Symbol

• C20orf74
• KIAA1272
• p220
• AS250
• C20orf74
• dJ1049G11
• bA287B20.1
• dJ1049G11.4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.9
histone modification site profile	0.74
transcription factor	0.74
transcription factor perturbation	0.74
transcription factor binding site profile	0.71

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Ral Gtpase-activating Protein Subunit Alpha-2

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Ral Gtpase-activating Protein Subunit Alpha-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.39   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 48   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.39   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0