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Tbio
RALGAPA1
Ral GTPase-activating protein subunit alpha-1

Protein Summary
Description
Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB. This gene encodes a major subunit of the RAL-GTPase activating protein. A similar protein in mouse binds E12, a transcriptional regulator of immunoglobulin genes. The mouse protein also functions in skeletal muscle by binding to the regulatory 14-3-3 proteins upon stimulation with insulin or muscle contraction. A pseudogene of this gene has been identified on chromosome 9. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307138
  • ENSP00000302647
  • ENSG00000174373
  • ENST00000382366
  • ENSP00000371803
  • ENST00000389698
  • ENSP00000374348
  • ENST00000553892
  • ENSP00000451877

Symbol
  • GARNL1
  • KIAA0884
  • TULIP1
  • p240
  • GRIPE
  • GARNL1
  • TULIP1
  • RalGAPalpha1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.79
virus perturbation
0.76
kinase perturbation
0.71
transcription factor
0.69
transcription factor binding site profile
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.93   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 69   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.93   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0