Tbio RAI14 Ankycorbin

Protein Summary

Description

Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier.

Uniprot Accession IDs

• Q9P0K7
• E9PED3
• Q6V1W9
• Q7Z5I4
• Q7Z733
• Q9P2L2
• Q9Y3T5

Gene Name

• RAI14

Ensembl ID

• ENST00000265109
• ENSP00000265109
• ENSG00000039560
• ENST00000428746
• ENSP00000388725
• ENST00000503673
• ENSP00000422942
• ENST00000506376
• ENSP00000423854
• ENST00000512629
• ENSP00000422377
• ENST00000515799
• ENSP00000427123

Symbol

• KIAA1334
• NORPEG
• RAI13
• NORPEG

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.93
PubMedID	0.86
transcription factor binding site profile	0.85
histone modification site profile	0.83
ligand (protein) perturbation	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.75   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 69   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.75   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0