Protein Summary
Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier.
- ENST00000265109
- ENSP00000265109
- ENSG00000039560
- ENST00000428746
- ENSP00000388725
- ENST00000503673
- ENSP00000422942
- ENST00000506376
- ENSP00000423854
- ENST00000512629
- ENSP00000422377
- ENST00000515799
- ENSP00000427123
- KIAA1334
- NORPEG
- RAI13
- NORPEG
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
kinase perturbation | 0.93 | ||
PubMedID | 0.86 | ||
transcription factor binding site profile | 0.85 | ||
histone modification site profile | 0.83 | ||
ligand (protein) perturbation | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.18 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 69 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.18 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 69 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (56)
VTN
Family: TF
Novelty: 0.00046861
p_int: 0.999998049
p_ni: 0.000001926
p_wrong: 2.5e-8
Data Source: BioPlex
VAPB
Novelty: 0.00542377
p_int: 0.999997148
p_ni: 0.000002851
p_wrong: 1e-9
Score: 0.182
Data Source: BioPlex,STRINGDB
PSMC3
Family: Enzyme
Novelty: 0.04026019
p_int: 0.999995204
p_ni: 0.000004796
Score: 0.349
Data Source: BioPlex,STRINGDB
PACSIN1
Family: Enzyme
Novelty: 0.01482925
p_int: 0.999972946
p_ni: 0.000027054
p_wrong: 1e-9
Score: 0.87
Data Source: BioPlex,STRINGDB
PLK1
Family: Kinase
Novelty: 0.00062799
p_int: 0.999958487
p_ni: 0.000041512
Score: 0.323
Data Source: BioPlex,STRINGDB
PARP16
Family: Enzyme
Novelty: 0.09651799
p_int: 0.999688757
p_ni: 0.000311243
Score: 0.204
Data Source: BioPlex,STRINGDB
VAPA
Novelty: 0.00169209
p_int: 0.99961064
p_ni: 0.00038936
Score: 0.179
Data Source: BioPlex,STRINGDB
CAV3
Novelty: 0.00190092
p_int: 0.998479736
p_ni: 0.001520259
p_wrong: 6e-9
Score: 0.167
Data Source: BioPlex,STRINGDB
FURIN
Family: Enzyme
Novelty: 0.00055079
p_int: 0.987791131
p_ni: 0.012208869
Data Source: BioPlex
BTRC
Novelty: 0.00293475
p_int: 0.987526414
p_ni: 0.012473583
p_wrong: 3e-9
Score: 0.165
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (8)
Components (6)
Processes (2)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
urate measurement | 2 | 2 | 2 | 86.6 | |||||
hemoglobin measurement | 2 | 2 | 2 | 81.8 | |||||
red blood cell density measurement | 1 | 1 | 1 | 70.5 | |||||
hematocrit | 1 | 1 | 1 | 67.7 | |||||
reticulocyte measurement | 2 | 1 | 2 | 54.4 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
urate measurement | 2 | 86.6 | |||||
hemoglobin measurement | 2 | 81.8 | |||||
red blood cell density measurement | 1 | 70.5 | |||||
hematocrit | 1 | 67.7 | |||||
reticulocyte measurement | 2 | 54.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | retinoic acid induced 14 | VGNC:7116 | 461932 | |||||
Macaque | retinoic acid induced 14 | 698620 | ||||||
Mouse | MGI:1922896 | 75646 | ||||||
Rat | RGD:1305942 | 294804 | ||||||
Dog | retinoic acid induced 14 | VGNC:45329 | 479368 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | retinoic acid induced 14 | |||||
Macaque | retinoic acid induced 14 | |||||
Mouse | ||||||
Rat | ||||||
Dog | retinoic acid induced 14 | |||||
Publication Statistics
PubMed Score 22.18
PubMed score by year
PubTator Score 6.09
PubTator score by year
Related Publications
Text Mined References (15)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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