Tbio RAI14 Ankycorbin

Protein Summary

Description

Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier.

Uniprot Accession IDs

• Q9P0K7
• E9PED3
• Q6V1W9
• Q7Z5I4
• Q7Z733
• Q9P2L2
• Q9Y3T5

Gene Name

• RAI14

Ensembl ID

• ENST00000265109
• ENSP00000265109
• ENSG00000039560
• ENST00000428746
• ENSP00000388725
• ENST00000503673
• ENSP00000422942
• ENST00000506376
• ENSP00000423854
• ENST00000512629
• ENSP00000422377
• ENST00000515799
• ENSP00000427123

Symbol

• KIAA1334
• NORPEG
• RAI13
• NORPEG

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.93
PubMedID	0.86
transcription factor binding site profile	0.85
histone modification site profile	0.83
ligand (protein) perturbation	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.18   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 69   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.18   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 69   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (56)

Explore Interacting Targets

1 – 10 of 56

• See Interactions on String-DB

VTN

Tbio

Family:  TF

Novelty:  0.00046861

p_int:  0.999998049

p_ni:  0.000001926

p_wrong:  2.5e-8

Data Source:  BioPlex

VAPB

Tbio

Novelty:  0.00542377

p_int:  0.999997148

p_ni:  0.000002851

p_wrong:  1e-9

Score:  0.182

Data Source:  BioPlex,STRINGDB

PSMC3

Tbio

Family:  Enzyme

Novelty:  0.04026019

p_int:  0.999995204

p_ni:  0.000004796

Score:  0.349

Data Source:  BioPlex,STRINGDB

PACSIN1

Tbio

Family:  Enzyme

Novelty:  0.01482925

p_int:  0.999972946

p_ni:  0.000027054

p_wrong:  1e-9

Score:  0.87

Data Source:  BioPlex,STRINGDB

PLK1

Tchem

Family:  Kinase

Novelty:  0.00062799

p_int:  0.999958487

p_ni:  0.000041512

Score:  0.323

Data Source:  BioPlex,STRINGDB

PARP16

Tchem

Family:  Enzyme

Novelty:  0.09651799

p_int:  0.999688757

p_ni:  0.000311243

Score:  0.204

Data Source:  BioPlex,STRINGDB

VAPA

Tbio

Novelty:  0.00169209

p_int:  0.99961064

p_ni:  0.00038936

Score:  0.179

Data Source:  BioPlex,STRINGDB

CAV3

Tbio

Novelty:  0.00190092

p_int:  0.998479736

p_ni:  0.001520259

p_wrong:  6e-9

Score:  0.167

Data Source:  BioPlex,STRINGDB

FURIN

Tchem

Family:  Enzyme

Novelty:  0.00055079

p_int:  0.987791131

p_ni:  0.012208869

Data Source:  BioPlex

BTRC

Tbio

Novelty:  0.00293475

p_int:  0.987526414

p_ni:  0.012473583

p_wrong:  3e-9

Score:  0.165

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (8)

Components (6)

Processes (2)

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1 – 6 of 6

GO Term	Evidence	Assigned by
cytosol	Inferred from Direct Assay (IDA)	HPA
fibrillar center	Inferred from Direct Assay (IDA)	HPA
nucleus	Inferred from Direct Assay (IDA)	HPA
cell cortex	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell
cell junction	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell
cytoskeleton	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell

Disease Associations ()

No disease associations found

GWAS Traits (9)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
urate measurement	EFO_0004531	2	2	2		86.6
hemoglobin measurement	EFO_0004509	2	2	2		81.8
red blood cell density measurement	EFO_0007978	1	1	1		70.5
hematocrit	EFO_0004348	1	1	1		67.7
reticulocyte measurement	EFO_0010700	2	1	2		54.4

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
urate measurement	EFO_0004531	2		86.6
hemoglobin measurement	EFO_0004509	2		81.8
red blood cell density measurement	EFO_0007978	1		70.5
hematocrit	EFO_0004348	1		67.7
reticulocyte measurement	EFO_0010700	2		54.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
ANK repeat
Cell junction
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Differentiation
Nucleus

GWAS Trait Find Similar Targets

No Header	No Header
hematocrit
hemoglobin measurement
low density lipoprotein cholesterol measurement
myeloid white cell count
platelet count
red blood cell density measurement
reticulocyte count
reticulocyte measurement
urate measurement

MGI Phenotype Find Similar Targets

No Header	No Header
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	retinoic acid induced 14	VGNC:7116	461932
Macaque	retinoic acid induced 14		698620
Mouse	retinoic acid induced 14	MGI:1922896	75646
Rat	retinoic acid induced 14	RGD:1305942	294804
Dog	retinoic acid induced 14	VGNC:45329	479368

Species	Name	OMA	EggNOG	Inparanoid
Chimp	retinoic acid induced 14
Macaque	retinoic acid induced 14
Mouse	retinoic acid induced 14
Rat	retinoic acid induced 14
Dog	retinoic acid induced 14

Publication Statistics

PubMed Score 22.18

PubMed score by year

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PubTator Score 6.09

PubTator score by year

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Related Publications

Text Mined References (15)

GeneRif Annotations (3)

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10

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PMID	Year	Title