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Tclin
RAF1
RAF proto-oncogene serine/threonine-protein kinase

Protein Summary
Description
Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in moti ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251849
  • ENSP00000251849
  • ENSG00000132155
  • ENST00000442415
  • ENSP00000401888

Symbol
  • RAF
  • NS5
  • CRAF
  • Raf-1
  • c-Raf
  • CMD1NN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
disease perturbation
1
hub protein
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 739.81   (req: < 5)
Gene RIFs: 237   (req: <= 3)
Antibodies: 2878   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 739.81   (req: >= 5)
Gene RIFs: 237   (req: > 3)
Antibodies: 2878   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 420
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (322)
BRAF
Tclin
Family:  Kinase
Novelty:  0.00253795
p_int:  0.999973271
p_ni:  0.000026729
Score:  0.952
Data Source:  BioPlex,Reactome,STRINGDB
HRAS
Tchem
Family:  Enzyme
Novelty:  0.00008069
Score:  0.999
Data Source:  Reactome,STRINGDB
RAP1A
Tchem
Family:  Enzyme
Novelty:  0.00375413
Score:  0.998
Data Source:  Reactome,STRINGDB
YWHAZ
Tchem
Novelty:  0.00210582
Score:  0.998
Data Source:  Reactome,STRINGDB
NRAS
Tchem
Family:  Enzyme
Novelty:  0.00080922
Score:  0.996
Data Source:  Reactome,STRINGDB
KRAS
Tclin
Family:  Enzyme
Novelty:  0.00013856
Score:  0.995
Data Source:  Reactome,STRINGDB
MAP2K1
Tclin
Family:  Kinase
Novelty:  0.0005278
Score:  0.989
Data Source:  Reactome,STRINGDB
YWHAB
Tchem
Novelty:  0.00614093
Score:  0.988
Data Source:  Reactome,STRINGDB
YWHAE
Tbio
Novelty:  0.00431876
Score:  0.988
Data Source:  STRINGDB
MAP2K2
Tclin
Family:  Kinase
Novelty:  0.00706525
Score:  0.988
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (274)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
C-type lectin receptors (CLRs)
Reactome
CD209 (DC-SIGN) signaling
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
C-type lectin receptors (CLRs)
CD209 (DC-SIGN) signaling
Cytokine Signaling in Immune system
Disease
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (54)
Find Similar Targets
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
10
10
88.7
BMI-adjusted waist-hip ratio
1
10
10
87.9
HbA1c measurement
1
2
2
84.5
hip circumference
1
6
6
83.2
total cholesterol measurement
2
3
3
79.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
10
88.7
BMI-adjusted waist-hip ratio
10
87.9
HbA1c measurement
2
84.5
hip circumference
6
83.2
total cholesterol measurement
3
79.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Raf-1 proto-oncogene, serine/threonine kinase
VGNC:12161
460182
Macaque
Raf-1 proto-oncogene, serine/threonine kinase
694725
Mouse
MGI:97847
110157
Rat
RGD:3531
24703
Dog
Raf-1 proto-oncogene, serine/threonine kinase
VGNC:45325
484648
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Raf-1 proto-oncogene, serine/threonine kinase
Macaque
Raf-1 proto-oncogene, serine/threonine kinase
Mouse
Rat
Dog
Raf-1 proto-oncogene, serine/threonine kinase
Publication Statistics
PubMed Score 739.81
PubMed score by year
PubTator Score 1441.82
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title