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Tbio
RAET1L
UL16-binding protein 6

Protein Summary
Description
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. RAET1L belongs to the RAET1 family of major histocompatibility complex (MHC) class I-related genes, which are located within a 180-kb cluster on chromosome 6q24.2-q25.3. The REAT1 genes encode glycoproteins that contain extracellular alpha-1 and alpha-2 domains, but they lack the membrane proximal Ig-like alpha-3 domain. Most RAET1 glycoproteins are anchored to the membrane via glycosylphosphatidylinositol (GPI) linkage (Radosavljevic et al., 2002 [PubMed 11827464]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286380
  • ENSP00000286380
  • ENSG00000155918
  • ENST00000367341
  • ENSP00000356310

Symbol
  • ULBP6
  • ULBP6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.64
cell type or tissue
0.63
histone modification site profile
0.48
phenotype
0.43
protein domain
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.74   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 4   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.74   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 4   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
KLRK1
Tbio
Novelty:  0.0009209
Score:  0.957
Data Source:  STRINGDB
LY6D
Tbio
Novelty:  0.07032941
Score:  0.91
Data Source:  STRINGDB
RAET1G
Tbio
Novelty:  0.14509419
Score:  0.906
Data Source:  STRINGDB
ULBP2
Tbio
Novelty:  0.01604318
Score:  0.905
Data Source:  STRINGDB
SPACA4
Tdark
Novelty:  0.21569953
Score:  0.904
Data Source:  STRINGDB
LYPD3
Tbio
Novelty:  0.03248533
Score:  0.903
Data Source:  STRINGDB
PSCA
Tbio
Novelty:  0.00323778
Score:  0.903
Data Source:  STRINGDB
MSLN
Tbio
Novelty:  0.00191245
Score:  0.903
Data Source:  STRINGDB
LY6K
Tbio
Novelty:  0.01861325
Score:  0.902
Data Source:  STRINGDB
THY1
Tbio
Novelty:  0.00032846
Score:  0.901
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.6
79.7
1
1
0
1.1
5.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
79.7
0
1.1
5.8
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Horse
NKG2D ligand 1
100063831
Species
Name
OMA
EggNOG
Inparanoid
Horse
NKG2D ligand 1
Publication Statistics
PubMed Score 5.74
PubMed score by year
PubTator Score 7.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title