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Tdark
RAD54L2
Helicase ARIP4

Protein Summary
Description
DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409535
  • ENSP00000386520
  • ENSG00000164080

Symbol
  • ARIP4
  • KIAA0809
  • ARIP4
  • HSPC325
  • SRISNF2L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
small molecule perturbation
0.64
cell line
0.62
tissue sample
0.59
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.89   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.89   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
PIAS4
Tbio
Family:  TF
Novelty:  0.01388547
p_int:  0.999997739
p_ni:  0.000002244
p_wrong:  1.7e-8
Score:  0.196
Data Source:  BioPlex,STRINGDB
DYRK1B
Tchem
Family:  Kinase
Novelty:  0.01960932
p_int:  0.999997502
p_ni:  0.000002496
p_wrong:  2e-9
Score:  0.193
Data Source:  BioPlex,STRINGDB
DCAF7
Tbio
Novelty:  0.02609518
p_int:  0.999971984
p_ni:  0.000027884
p_wrong:  1.32e-7
Score:  0.52
Data Source:  BioPlex,STRINGDB
ADPRHL2
Tbio
Family:  Enzyme
Novelty:  0.02261777
p_int:  0.998325612
p_ni:  0.001674388
p_wrong:  1e-9
Data Source:  BioPlex
DYRK1A
Tchem
Family:  Kinase
Novelty:  0.00226963
p_int:  0.997312181
p_ni:  0.002687796
p_wrong:  2.3e-8
Score:  0.607
Data Source:  BioPlex,STRINGDB
PCDHAC2
Tdark
Novelty:  0.28397695
p_int:  0.760256327
p_ni:  0.000076634
p_wrong:  0.239667039
Score:  0.218
Data Source:  BioPlex,STRINGDB
AR
Tclin
Family:  NR
Novelty:  0.00013531
Score:  0.767
Data Source:  STRINGDB
BRCA1
Tchem
Novelty:  0.00011146
Score:  0.729
Data Source:  STRINGDB
ERC2
Tbio
Novelty:  0.00953771
Score:  0.659
Data Source:  STRINGDB
CACNA2D3
Tbio
Family:  IC
Novelty:  0.05267262
Score:  0.608
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
58.4
mathematical ability
1
1
1
46.1
testosterone measurement
1
1
1
42.3
macrophage inflammatory protein 1b measurement
1
2
2
40.4
self reported educational attainment
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
58.4
mathematical ability
1
46.1
testosterone measurement
1
42.3
macrophage inflammatory protein 1b measurement
2
40.4
self reported educational attainment
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAD54 like 2
745605
Macaque
RAD54 like 2 [Source:HGNC Symbol;Acc:HGNC:29123]
Mouse
MGI:1933196
81000
Rat
RGD:1561889
363135
Dog
RAD54 like 2
VGNC:49612
476608
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAD54 like 2
Macaque
RAD54 like 2 [Source:HGNC Symbol;Acc:HGNC:29123]
Mouse
Rat
Dog
RAD54 like 2
Publication Statistics
PubMed Score 4.89
PubMed score by year
PubTator Score 4.15
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title