Tchem RAD52 DNA repair protein RAD52 homolog

Protein Summary

Description

Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase. The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. A pseudogene of this gene is present on chromosome 2. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• P43351
• Q13205
• Q9Y5T7
• Q9Y5T8
• Q9Y5T9

Gene Name

• RAD52

Ensembl ID

• ENST00000358495
• ENSP00000351284
• ENSG00000002016
• ENST00000430095
• ENSP00000387901
• ENST00000461568
• ENSP00000436008
• ENST00000468231
• ENSP00000434703
• ENST00000541619
• ENSP00000438965
• ENST00000544742
• ENSP00000443254
• ENST00000545564
• ENSP00000440268

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.88
transcription factor binding site profile	0.86
histone modification site profile	0.83
tissue	0.63
cellular component	0.62

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Repair Protein Rad52 Homolog

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Repair Protein Rad52 Homolog

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 876   (req: < 5)

Gene RIFs: 94   (req: <= 3)

Antibodies: 372   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 876   (req: >= 5)

Gene RIFs: 94   (req: > 3)

Antibodies: 372   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 36

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0