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Tbio
RAD51C
DNA repair protein RAD51 homolog 3

Protein Summary
Description
Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD21 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. Involved in RAD51 foci formation in response ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337432
  • ENSP00000336701
  • ENSG00000108384
  • ENST00000421782
  • ENSP00000391450

Symbol
  • RAD51L2
  • FANCO
  • R51H3
  • BROVCA3
  • RAD51L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
histone modification site profile
0.89
kinase perturbation
0.88
transcription factor binding site profile
0.81
protein domain
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.03   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 352   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.03   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 352   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (217)
KLHL10
Tdark
Novelty:  0.09497583
p_int:  0.999996895
p_ni:  0.000003105
Score:  0.167
Data Source:  BioPlex,STRINGDB
PTPN9
Tchem
Family:  Enzyme
Novelty:  0.01574113
p_int:  0.999060315
p_ni:  0.000939685
Score:  0.188
Data Source:  BioPlex,STRINGDB
XRCC2
Tbio
Novelty:  0.00862049
p_int:  0.994666946
p_ni:  0.005333054
Score:  0.98
Data Source:  BioPlex,Reactome,STRINGDB
CCDC140
Tdark
Novelty:  2.54113496
p_int:  0.988756179
p_ni:  0.001419398
p_wrong:  0.009824423
Score:  0.282
Data Source:  BioPlex,STRINGDB
SPACA1
Tbio
Novelty:  0.07415851
p_int:  0.918267139
p_ni:  0.081732861
Data Source:  BioPlex
EFNB3
Tbio
Novelty:  0.0120367
p_int:  0.88732406
p_ni:  0.11267594
Data Source:  BioPlex
DKKL1
Tbio
Novelty:  0.00544618
p_int:  0.801493754
p_ni:  0.198506246
Data Source:  BioPlex
FAM174A
Tdark
Novelty:  0.30693139
p_int:  0.778536285
p_ni:  0.221463715
Data Source:  BioPlex
ADAMTS4
Tchem
Family:  Enzyme
Novelty:  0.00424194
p_int:  0.761509157
p_ni:  0.238490843
Data Source:  BioPlex
HENMT1
Tdark
Family:  Enzyme
Novelty:  0.17427834
p_int:  0.756103317
p_ni:  0.243896683
Score:  0.228
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
HDR through Homologous Recombination (HRR)
Name
Explore in Pharos
Explore in Source
Cell Cycle
DNA Double-Strand Break Repair
DNA Repair
Factors involved in megakaryocyte development and platelet production
HDR through Homologous Recombination (HRR)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
1
1
66.8
iron biomarker measurement
1
1
1
60.1
ferritin measurement
1
1
1
60.1
neutrophil count
1
1
1
55
tooth eruption
1
1
1
52.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
66.8
iron biomarker measurement
1
60.1
ferritin measurement
1
60.1
neutrophil count
1
55
tooth eruption
1
52.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAD51 paralog C
VGNC:9552
455162
Macaque
RAD51 paralog C
714828
Mouse
MGI:2150020
114714
Rat
RGD:1563765
497976
Dog
RAD51 paralog C
VGNC:45319
480573
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAD51 paralog C
Macaque
RAD51 paralog C
Mouse
Rat
Dog
RAD51 paralog C
Publication Statistics
PubMed Score 172.03
PubMed score by year
PubTator Score 99.02
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title