You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RAD51B
DNA repair protein RAD51 homolog 2

Protein Summary
Description
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. The protein encoded by this gene is a member of the RAD5 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000471583
  • ENSP00000418859
  • ENSG00000182185
  • ENST00000487270
  • ENSP00000419471
  • ENST00000488612
  • ENSP00000420061

Symbol
  • RAD51L1
  • REC2
  • REC2
  • R51H2
  • RAD51L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
trait
0.86
disease
0.73
protein domain
0.73
transcription factor binding site profile
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 313.19   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 267   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 313.19   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (215)
XRCC2
Tbio
Novelty:  0.00862049
p_int:  0.999935327
p_ni:  0.000064673
Score:  0.989
Data Source:  BioPlex,Reactome,STRINGDB
DKKL1
Tbio
Novelty:  0.00544618
p_int:  0.999410786
p_ni:  0.000589213
p_wrong:  1e-9
Data Source:  BioPlex
ARL4C
Tbio
Family:  Enzyme
Novelty:  0.04764628
p_int:  0.994077031
p_ni:  0.005909009
p_wrong:  0.000013961
Score:  0.554
Data Source:  BioPlex,STRINGDB
MUC20
Tbio
Novelty:  0.04645313
p_int:  0.95164372
p_ni:  0.048332776
p_wrong:  0.000023504
Data Source:  BioPlex
ADAMTS4
Tchem
Family:  Enzyme
Novelty:  0.00424194
p_int:  0.946915717
p_ni:  0.00386059
p_wrong:  0.049223693
Score:  0.161
Data Source:  BioPlex,STRINGDB
BRCA1
Tchem
Novelty:  0.00011146
Score:  0.992
Data Source:  STRINGDB
BRCA2
Tbio
Novelty:  0.0002217
Score:  0.992
Data Source:  STRINGDB
RAD51D
Tbio
Novelty:  0.01422516
Score:  0.991
Data Source:  Reactome,STRINGDB
RAD1
Tchem
Novelty:  0.0060275
Score:  0.99
Data Source:  STRINGDB
MRE11
Tbio
Novelty:  0.01038348
Score:  0.978
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
DNA Double-Strand Break Repair (R-HSA-5693532)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
HDR through Homologous Recombination (HRR)
Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Name
Explore in Pharos
Explore in Source
DNA Double-Strand Break Repair
DNA Repair
Factors involved in megakaryocyte development and platelet production
HDR through Homologous Recombination (HRR)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (70)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
3
3
2
3.2
96.5
mean platelet volume
2
4
4
93.6
platelet crit
2
3
3
91.3
4
3
0
1.1
89.3
childhood onset asthma
2
2
0
1.1
88.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
3.2
96.5
mean platelet volume
4
93.6
platelet crit
3
91.3
0
1.1
89.3
childhood onset asthma
0
1.1
88.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAD51 paralog B
VGNC:12592
467487
Macaque
RAD51 paralog B
711358
Mouse
MGI:1099436
19363
Dog
RAD51 paralog B [Source:HGNC Symbol;Acc:HGNC:9822]
Horse
RAD51 paralog B [Source:HGNC Symbol;Acc:HGNC:9822]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAD51 paralog B
Macaque
RAD51 paralog B
Mouse
Dog
RAD51 paralog B [Source:HGNC Symbol;Acc:HGNC:9822]
Horse
RAD51 paralog B [Source:HGNC Symbol;Acc:HGNC:9822]
Publication Statistics
PubMed Score 313.19
PubMed score by year
PubTator Score 72.33
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title