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Tbio
RAD51AP1
RAD51-associated protein 1

Protein Summary
Description
May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Functionally cooperates with PALB2 in promoting of D-loop formation by RAD51. Binds to single and double stranded DNA, and is capable of aggregating DNA. Also binds RNA.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228843
  • ENSP00000228843
  • ENSG00000111247
  • ENST00000352618
  • ENSP00000309479

Symbol
  • PIR51
  • PIR51
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
kinase perturbation
0.71
transcription factor binding site profile
0.71
PubMedID
0.69
disease perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.55   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.55   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (246)
USP46
Tbio
Family:  Enzyme
Novelty:  0.04594593
p_int:  0.999990973
p_ni:  0.000009026
Score:  0.765
Data Source:  BioPlex,STRINGDB
WDR48
Tbio
Novelty:  0.04070481
p_int:  0.999544402
p_ni:  0.000455598
Score:  0.939
Data Source:  BioPlex,STRINGDB
IGHG4
Tclin
p_int:  0.998436853
p_ni:  0.000142657
p_wrong:  0.001420489
Data Source:  BioPlex
IGHG3
Tclin
p_int:  0.997184821
p_ni:  0.00066134
p_wrong:  0.002153839
Data Source:  BioPlex
JUP
Tbio
Novelty:  0.0081803
p_int:  0.915980396
p_ni:  0.084019604
Score:  0.295
Data Source:  BioPlex,STRINGDB
USP1
Tchem
Family:  Enzyme
Novelty:  0.0092606
p_int:  0.88575481
p_ni:  0.11424519
Score:  0.901
Data Source:  BioPlex,STRINGDB
RAD51
Tchem
Novelty:  0.00011516
Score:  0.993
Data Source:  Reactome,STRINGDB
POLE2
Tbio
Family:  Enzyme
Novelty:  0.03129531
Score:  0.985
Data Source:  STRINGDB
EXO1
Tbio
Family:  Enzyme
Novelty:  0.00130104
Score:  0.983
Data Source:  STRINGDB
PALB2
Tbio
Novelty:  0.00320056
Score:  0.977
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
DNA Double-Strand Break Repair (R-HSA-5693532)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
HDR through Homologous Recombination (HRR)
Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Reactome
Homologous DNA Pairing and Strand Exchange
Name
Explore in Pharos
Explore in Source
DNA Double-Strand Break Repair
DNA Repair
HDR through Homologous Recombination (HRR)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Homologous DNA Pairing and Strand Exchange
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
1
1
7.5
81.5
glomerular filtration rate
2
2
2
42
calcium measurement
1
1
1
35
phosphorus measurement
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
7.5
81.5
glomerular filtration rate
2
42
calcium measurement
1
35
phosphorus measurement
1
30.2
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAD51 associated protein 1
VGNC:5562
451765
Macaque
RAD51 associated protein 1
710918
Mouse
MGI:1098224
19362
Rat
RGD:1597431
689055
Dog
RAD51 associated protein 1
VGNC:45318
611768
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAD51 associated protein 1
Macaque
RAD51 associated protein 1
Mouse
Rat
Dog
RAD51 associated protein 1
Publication Statistics
PubMed Score 27.55
PubMed score by year
PubTator Score 8.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title