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Tdark
RAD21L1
Double-strand-break repair protein rad21-like protein 1

Protein Summary
Description
Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000402452
  • ENSP00000385925
  • ENSG00000244588
  • ENST00000409241
  • ENSP00000386414

Symbol
  • RAD21L
  • RAD21L
  • dJ545L17.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.76
histone modification site profile
0.68
tissue sample
0.51
biological process
0.46
phenotype
0.45


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.08   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 10   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.08   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 10   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (111)
SMC3
Tbio
Novelty:  0.00474377
Score:  0.99
Data Source:  STRINGDB
STAG3
Tbio
Novelty:  0.03329703
Score:  0.99
Data Source:  STRINGDB
SMC1B
Tbio
Novelty:  0.0369537
Score:  0.988
Data Source:  STRINGDB
STAG1
Tbio
Novelty:  0.00122511
Score:  0.975
Data Source:  STRINGDB
SMC1A
Tchem
Novelty:  0.00898427
Score:  0.975
Data Source:  STRINGDB
STAG2
Tbio
Novelty:  0.00430441
Score:  0.961
Data Source:  STRINGDB
WAPL
Tbio
Novelty:  0.01598061
Score:  0.903
Data Source:  STRINGDB
PDS5A
Tbio
Novelty:  0.0142948
Score:  0.887
Data Source:  STRINGDB
PDS5B
Tbio
Novelty:  0.00295057
Score:  0.884
Data Source:  STRINGDB
SGO2
Tbio
Novelty:  0.05544423
Score:  0.85
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
2
2
74.1
white matter microstructure measurement
1
1
0
1.3
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
74.1
white matter microstructure measurement
0
1.3
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:3652039
668929
Rat
RGD:1587557
689823
Dog
RAD21 cohesin complex component like 1
VGNC:45314
609572
Horse
RAD21 cohesin complex component like 1
VGNC:22145
100146626
Cow
RAD21 cohesin complex component like 1
VGNC:33681
512408
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
RAD21 cohesin complex component like 1
Horse
RAD21 cohesin complex component like 1
Cow
RAD21 cohesin complex component like 1
Publication Statistics
PubMed Score 11.08
PubMed score by year
PubTator Score 4.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title