Tchem RAD1 Cell cycle checkpoint protein RAD1

Protein Summary

Description

Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:10846170, PubMed:10884395). The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:12578958). Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:15871698). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:15314187, PubMed:15556996, PubMed:15871698). The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603). Isoform 1 possesses 3'->5' double stranded DNA exonuclease activity (PubMed:9660799). This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jan 2009]

Uniprot Accession IDs

• O60671
• O75572
• O95304
• Q1W161
• Q5KSM0
• Q5KSM1
• Q9UEP1
• hRAD1

Gene Name

• RAD1

Ensembl ID

• ENST00000325577
• ENSP00000313467
• ENSG00000113456
• ENST00000341754
• ENSP00000340879
• ENST00000382038
• ENSP00000371469

Symbol

• REC1
• REC1
• HRAD1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.9
virus perturbation	0.9
transcription factor binding site profile	0.82
kinase perturbation	0.71
tissue sample	0.7

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / Exodeoxyribonuclease / Cell Cycle Checkpoint Protein Rad1

Protein / Nucleic Acid Binding / Dna Binding Protein / Exodeoxyribonuclease / Cell Cycle Checkpoint Protein Rad1

Protein / Hydrolase / Cell Cycle Checkpoint Protein Rad1

DTO Classes

Protein / Enzyme / Nuclease / Exodeoxyribonuclease / Cell Cycle Checkpoint Protein Rad1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.47   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 310   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.47   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 310   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0