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Tbio
RAC3
Ras-related C3 botulinum toxin substrate 3

Protein Summary
Description
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner. The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306897
  • ENSP00000304283
  • ENSG00000169750
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
cellular component
0.77
hub protein
0.75
small molecule perturbation
0.75
disease
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.83   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.83   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (373)
RAC2
Tbio
Family:  Enzyme
Novelty:  0.00116234
p_int:  0.999999905
p_wrong:  9.4e-8
Score:  0.985
Data Source:  BioPlex,STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
p_int:  0.999998458
p_ni:  0.000001434
p_wrong:  1.07e-7
Score:  0.982
Data Source:  BioPlex,STRINGDB
RAP1GDS1
Tbio
Family:  Enzyme
Novelty:  0.06140479
p_int:  0.999944471
p_ni:  0.000049086
p_wrong:  0.000006443
Score:  0.748
Data Source:  BioPlex,STRINGDB
SLC7A1
Tbio
Family:  Transporter
Novelty:  0.00197313
p_int:  0.999906743
p_ni:  0.000093252
p_wrong:  5e-9
Score:  0.18
Data Source:  BioPlex,STRINGDB
SLC9A6
Tbio
Family:  Transporter
Novelty:  0.01410234
p_int:  0.999889164
p_ni:  0.000110828
p_wrong:  7e-9
Score:  0.214
Data Source:  BioPlex,STRINGDB
IQGAP3
Tbio
Family:  Enzyme
Novelty:  0.05874747
p_int:  0.999832042
p_ni:  0.000167791
p_wrong:  1.67e-7
Score:  0.879
Data Source:  BioPlex,STRINGDB
LY86
Tbio
Novelty:  0.00314575
p_int:  0.999083264
p_ni:  0.000620223
p_wrong:  0.000296513
Data Source:  BioPlex
TGFA
Tbio
Novelty:  0.00216159
p_int:  0.999042348
p_ni:  0.000668705
p_wrong:  0.000288947
Data Source:  BioPlex
PLAC9
Tdark
Novelty:  0.23764669
p_int:  0.996368876
p_ni:  0.00362877
p_wrong:  0.000002354
Data Source:  BioPlex
ARHGEF7
Tbio
Novelty:  0.00919946
p_int:  0.995176973
p_ni:  0.004819752
p_wrong:  0.000003275
Score:  0.958
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (8)
Explore Nearest Tclin Targets
1 – 4 of 4
SRC
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  10
more:  6 more common pathways
PIK3CD
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  20
more:  16 more common pathways
PIK3CA
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  20
more:  16 more common pathways
Pathways (52)
Beta-catenin independent WNT signaling (R-HSA-3858494)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
PCP/CE pathway
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
PCP/CE pathway
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
5
6
76.5
vital capacity
1
1
1
73.2
BMI-adjusted waist-hip ratio
2
3
3
58.3
blood metabolite measurement
1
1
1
57.3
birth weight
2
2
2
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
6
76.5
vital capacity
1
73.2
BMI-adjusted waist-hip ratio
3
58.3
blood metabolite measurement
1
57.3
birth weight
2
55.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2180784
170758
Cow
Rac family small GTPase 3
619066
Opossum
Rac family small GTPase 3
100029873
Anole lizard
Rac family small GTPase 3
100568092
Zebrafish
ZDB-GENE-080220-21
795167
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Cow
Rac family small GTPase 3
Opossum
Rac family small GTPase 3
Anole lizard
Rac family small GTPase 3
Zebrafish
Publication Statistics
PubMed Score 30.83
PubMed score by year
PubTator Score 77.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title