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Tbio
RAC1
Ras-related C3 botulinum toxin substrate 1

Protein Summary
Description
Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phospho ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348035
  • ENSP00000258737
  • ENSG00000136238
  • ENST00000356142
  • ENSP00000348461

Symbol
  • TC25
  • MIG5
  • MRD48
  • Rac-1
  • TC-25
  • p21-Rac1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
disease perturbation
1
hub protein
1
interacting protein
1
kinase perturbation
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 300.78   (req: < 5)
Gene RIFs: 742   (req: <= 3)
Antibodies: 623   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 300.78   (req: >= 5)
Gene RIFs: 742   (req: > 3)
Antibodies: 623   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 66
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (630)
RAC3
Tbio
Family:  Enzyme
Novelty:  0.02125361
p_int:  0.999998458
p_ni:  0.000001434
p_wrong:  1.07e-7
Score:  0.982
Data Source:  BioPlex,STRINGDB
POLA2
Tbio
Family:  Enzyme
Novelty:  0.07371844
p_int:  0.999952355
p_ni:  0.000047645
Score:  0.189
Data Source:  BioPlex,STRINGDB
LACC1
Tbio
Family:  Enzyme
Novelty:  0.03928871
p_int:  0.999362472
p_ni:  0.000593539
p_wrong:  0.000043988
Data Source:  BioPlex
RHEB
Tbio
Family:  Enzyme
Novelty:  0.00313935
p_int:  0.986098497
p_ni:  0.013901503
Score:  0.324
Data Source:  BioPlex,STRINGDB
TRAF7
Tbio
Family:  Enzyme
Novelty:  0.02437761
p_int:  0.955666349
p_ni:  0.044332136
p_wrong:  0.000001516
Score:  0.171
Data Source:  BioPlex,STRINGDB
RAP1GDS1
Tbio
Family:  Enzyme
Novelty:  0.06140479
p_int:  0.932826367
p_ni:  0.067173633
Score:  0.932
Data Source:  BioPlex,STRINGDB
GRB2
Tchem
Novelty:  0.00091605
p_int:  0.805794822
p_ni:  0.194205178
Score:  0.596
Data Source:  BioPlex,Reactome,STRINGDB
ARFIP2
Tbio
Novelty:  0.01200959
Score:  0.995
Data Source:  STRINGDB
WAS
Tbio
Novelty:  0.00087362
Score:  0.995
Data Source:  STRINGDB
ARHGDIA
Tchem
Novelty:  0.001991
Score:  0.992
Data Source:  STRINGDB
Nearest Tclin Targets (7)
Explore Nearest Tclin Targets
1 – 5 of 5
PIK3CA
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  34
more:  30 more common pathways
PIK3CD
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  34
more:  30 more common pathways
SRC
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  17
more:  13 more common pathways
ABL1
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  6
more:  2 more common pathways
Pathways (268)
Activated NTRK2 signals through CDK5 (R-HSA-9032845)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 95
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NTRK2 signals through CDK5
Reactome
Activated NTRK2 signals through FYN
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Activation of RAC1
Reactome
Activation of RAC1 downstream of NMDARs
Name
Explore in Pharos
Explore in Source
Activated NTRK2 signals through CDK5
Activated NTRK2 signals through FYN
Activation of NMDA receptors and postsynaptic events
Activation of RAC1
Activation of RAC1 downstream of NMDARs
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (85)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
6
3
8
95.6
monocyte count
6
3
6
94.6
neutrophil percentage of leukocytes
2
3
3
87.6
lymphocyte percentage of leukocytes
2
3
3
84
red blood cell distribution width
3
4
4
83.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
8
95.6
monocyte count
6
94.6
neutrophil percentage of leukocytes
3
87.6
lymphocyte percentage of leukocytes
3
84
red blood cell distribution width
4
83.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
741907
Mouse
MGI:97845
19353
Rat
RGD:619755
363875
Dog
Rac family small GTPase 1
VGNC:49609
403955
Cow
Rac family small GTPase 1
281440
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Mouse
Rat
Dog
Rac family small GTPase 1
Cow
Rac family small GTPase 1
Publication Statistics
PubMed Score 300.78
PubMed score by year
PubTator Score 1982.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title