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Tbio
RABL2A
Rab-like protein 2A

Protein Summary
Description
Plays an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins including key proteins involved in cilia development and function and delivers them into the growing sperm tail. This gene is a member of the RAB gene family which belongs to the RAS GTPase superfamily. The proteins in the family of RAS-related signaling molecules are small GTP-binding proteins that play important roles in the regulation of exocytotic and endocytotic pathways. This gene maps to the site of an ancestral telomere fusion event and may be a subtelomeric gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393165
  • ENSP00000376870
  • ENSG00000144134
  • ENST00000393166
  • ENSP00000376871
  • ENST00000393167
  • ENSP00000376872
  • ENST00000409875
  • ENSP00000387229
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
histone modification site profile
0.83
interacting protein
0.71
tissue sample
0.55
transcription factor perturbation
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.14   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.14   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
CCDC34
Tbio
Novelty:  0.31079723
p_int:  0.999999821
p_ni:  1.78e-7
p_wrong:  1e-9
Score:  0.519
Data Source:  BioPlex,STRINGDB
RPP25
Tbio
Family:  Enzyme
Novelty:  0.07178063
p_int:  0.999937687
p_ni:  0.000062313
Score:  0.175
Data Source:  BioPlex,STRINGDB
CEP19
Tbio
Novelty:  0.20749222
p_int:  0.99945384
p_ni:  0.000139531
p_wrong:  0.000406628
Score:  0.638
Data Source:  BioPlex,STRINGDB
FIGNL1
Tbio
Family:  Enzyme
Novelty:  0.10817841
p_int:  0.993829437
p_ni:  0.002834408
p_wrong:  0.003336155
Score:  0.213
Data Source:  BioPlex,STRINGDB
FHIT
Tchem
Family:  Enzyme
Novelty:  0.0012803
p_int:  0.911219662
p_ni:  0.039078108
p_wrong:  0.04970223
Score:  0.318
Data Source:  BioPlex,STRINGDB
ALMS1
Tbio
Novelty:  0.00694228
p_int:  0.897361466
p_ni:  0.102638534
Score:  0.193
Data Source:  BioPlex,STRINGDB
SEC23IP
Tbio
Novelty:  0.0925721
p_int:  0.857524404
p_ni:  0.14231964
p_wrong:  0.000155956
Score:  0.205
Data Source:  BioPlex,STRINGDB
MTO1
Tbio
Novelty:  0.0229161
p_int:  0.807644878
p_ni:  0.103158548
p_wrong:  0.089196574
Score:  0.185
Data Source:  BioPlex,STRINGDB
BRCA2
Tbio
Novelty:  0.0002217
p_int:  0.776518255
p_ni:  0.223481745
Score:  0.171
Data Source:  BioPlex,STRINGDB
APPL2
Tbio
Novelty:  0.18610793
Score:  0.917
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 11.14
PubMed score by year
PubTator Score 2.77
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title