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Tbio
RABGAP1
Rab GTPase-activating protein 1

Protein Summary
Description
May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373647
  • ENSP00000362751
  • ENSG00000011454
  • ENST00000456584
  • ENSP00000414386

Symbol
  • GAPCENA
  • TBC1D11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
disease perturbation
0.83
microRNA
0.73
protein domain
0.73
molecular function
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.45   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 264   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.45   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
WASHC3
Tdark
Novelty:  0.18307321
p_int:  0.999999911
p_ni:  8.9e-8
Data Source:  BioPlex
CORO1A
Tbio
Novelty:  0.00898925
p_int:  0.999999693
p_ni:  3.07e-7
Score:  0.161
Data Source:  BioPlex,STRINGDB
TUFT1
Tbio
Novelty:  0.01999031
p_int:  0.999999539
p_ni:  4.61e-7
Score:  0.604
Data Source:  BioPlex,STRINGDB
HOXC4
Tbio
Family:  TF
Novelty:  0.02206351
p_int:  0.999999083
p_ni:  9.17e-7
Score:  0.191
Data Source:  BioPlex,STRINGDB
VIPR2
Tchem
Family:  GPCR
Novelty:  0.00463802
p_int:  0.999998734
p_ni:  0.000001266
Data Source:  BioPlex
TRIM11
Tbio
Family:  Enzyme
Novelty:  0.02243955
p_int:  0.99990841
p_ni:  0.00009159
Data Source:  BioPlex
GGA1
Tbio
Novelty:  0.00866392
p_int:  0.999487099
p_ni:  0.000512901
Score:  0.279
Data Source:  BioPlex,STRINGDB
ECSCR
Tbio
Novelty:  0.11603718
p_int:  0.998903674
p_ni:  0.001096326
Data Source:  BioPlex
KIR2DS2
Tdark
p_int:  0.998761132
p_ni:  0.001238868
Data Source:  BioPlex
FIS1
Tbio
Novelty:  0.0033607
p_int:  0.998171301
p_ni:  0.001828699
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
Rab regulation of trafficking
Reactome
TBC/RABGAPs
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
Rab regulation of trafficking
TBC/RABGAPs
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
3
3
3
79.3
insomnia measurement
1
2
0
1.1
57.1
body height
1
1
1
55.2
1
1
1
54.4
body height at birth
1
1
1
53.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
birth weight
3
79.3
insomnia measurement
0
1.1
57.1
body height
1
55.2
1
54.4
body height at birth
1
53.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2385139
227800
Rat
RGD:1304691
311911
Dog
RAB GTPase activating protein 1
480734
Horse
RAB GTPase activating protein 1
100067385
Opossum
RAB GTPase activating protein 1
100015268
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
RAB GTPase activating protein 1
Horse
RAB GTPase activating protein 1
Opossum
RAB GTPase activating protein 1
Publication Statistics
PubMed Score 6.45
PubMed score by year
PubTator Score 3.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title