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Tdark
RABEPK
Rab9 effector protein with kelch motifs

Protein Summary
Description
Rab9 effector required for endosome to trans-Golgi network (TGN) transport.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259460
  • ENSP00000259460
  • ENSG00000136933
  • ENST00000373538
  • ENSP00000362639
  • ENST00000394125
  • ENSP00000377683

Symbol
  • RAB9P40
  • p40
  • RAB9P40
  • bA65N13.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
transcription factor perturbation
0.94
virus perturbation
0.94
histone modification site profile
0.85
cell type or tissue
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.68   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.68   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
ST3GAL3
Tbio
Family:  Enzyme
Novelty:  0.01592595
p_int:  0.999998712
p_ni:  4.54e-7
p_wrong:  8.34e-7
Data Source:  BioPlex
TESK1
Tchem
Family:  Kinase
Novelty:  0.06769478
p_int:  0.999946812
p_ni:  1.1e-8
p_wrong:  0.000053177
Data Source:  BioPlex
CFAP20
Tbio
Novelty:  0.01299681
p_int:  0.999788697
p_ni:  0.000211303
Score:  0.241
Data Source:  BioPlex,STRINGDB
GMEB1
Tbio
Family:  TF
Novelty:  0.10522678
p_int:  0.999338254
p_ni:  0.000548643
p_wrong:  0.000113104
Data Source:  BioPlex
MISP
Tbio
Novelty:  0.02030151
p_int:  0.992679893
p_ni:  0.007320107
Score:  0.237
Data Source:  BioPlex,STRINGDB
CACNG5
Tdark
Family:  IC
Novelty:  0.52705448
p_int:  0.960911057
p_ni:  0.039088943
Score:  0.161
Data Source:  BioPlex,STRINGDB
RAB9A
Tbio
Family:  Enzyme
Novelty:  0.07006531
Score:  0.953
Data Source:  Reactome,STRINGDB
VPS53
Tbio
Novelty:  0.07513165
Score:  0.936
Data Source:  Reactome,STRINGDB
PLIN3
Tbio
Novelty:  0.00975965
Score:  0.918
Data Source:  STRINGDB
VPS52
Tbio
Novelty:  0.01439614
Score:  0.914
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Membrane Trafficking
Reactome
Retrograde transport at the Trans-Golgi-Network
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Membrane Trafficking
Retrograde transport at the Trans-Golgi-Network
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking cessation
2
1
2
80.1
1
1
1
73.9
substance abuse
1
1
1
73.9
antisocial behaviour measurement
1
1
1
73.9
smoking status measurement
2
2
2
71.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking cessation
2
80.1
1
73.9
substance abuse
1
73.9
antisocial behaviour measurement
1
73.9
smoking status measurement
2
71.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rab9 effector protein with kelch motifs
VGNC:13949
738599
Macaque
Rab9 effector protein with kelch motifs
712731
Mouse
MGI:2139530
227746
Rat
RGD:1310612
296649
Dog
Rab9 effector protein with kelch motifs
VGNC:45302
609581
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rab9 effector protein with kelch motifs
Macaque
Rab9 effector protein with kelch motifs
Mouse
Rat
Dog
Rab9 effector protein with kelch motifs
Publication Statistics
PubMed Score 1.68
PubMed score by year
PubTator Score 0.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title