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Tbio
RABAC1
Prenylated Rab acceptor protein 1

Protein Summary
Description
General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222008
  • ENSP00000222008
  • ENSG00000105404

Symbol
  • PRA1
  • PRAF1
  • PRA1
  • YIP3
  • PRAF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
kinase perturbation
0.88
interacting protein
0.84
transcription factor binding site profile
0.75
hub protein
0.71


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.77   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.77   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0