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Tbio
RABAC1
Prenylated Rab acceptor protein 1

Protein Summary
Description
General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222008
  • ENSP00000222008
  • ENSG00000105404

Symbol
  • PRA1
  • PRAF1
  • PRA1
  • YIP3
  • PRAF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
kinase perturbation
0.88
interacting protein
0.84
transcription factor binding site profile
0.75
hub protein
0.71


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.19   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.19   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
RTN4
Tbio
Novelty:  0.00080371
p_int:  0.999960586
p_ni:  0.000015125
p_wrong:  0.000024289
Score:  0.766
Data Source:  BioPlex,STRINGDB
RAB43
Tbio
Family:  Enzyme
Novelty:  0.07527576
p_int:  0.997984936
p_ni:  0.00196339
p_wrong:  0.000051674
Score:  0.409
Data Source:  BioPlex,STRINGDB
RAB2B
Tbio
Family:  Enzyme
Novelty:  0.18567584
p_int:  0.997344669
p_ni:  0.002435663
p_wrong:  0.000219667
Score:  0.299
Data Source:  BioPlex,STRINGDB
REEP5
Tbio
Novelty:  0.00160455
p_int:  0.997260448
p_ni:  0.000044477
p_wrong:  0.002695075
Score:  0.596
Data Source:  BioPlex,STRINGDB
TMEM208
Tdark
Novelty:  0.63059333
p_int:  0.996208416
p_ni:  0.003736893
p_wrong:  0.000054691
Data Source:  BioPlex
EPHB6
Tchem
Family:  Kinase
Novelty:  0.02310045
p_int:  0.924865061
p_ni:  0.001880978
p_wrong:  0.073253961
Data Source:  BioPlex
FAM241A
Tdark
Novelty:  1.04041354
p_int:  0.890605753
p_ni:  0.002099099
p_wrong:  0.107295148
Data Source:  BioPlex
NAT8B
Tbio
Family:  Enzyme
p_int:  0.84000301
p_ni:  0.001188795
p_wrong:  0.158808195
Data Source:  BioPlex
TMEM128
Tdark
Novelty:  5.15874803
p_int:  0.832487385
p_ni:  0.000286352
p_wrong:  0.167226263
Score:  0.827
Data Source:  BioPlex,STRINGDB
CYP2A6
Tchem
Novelty:  0.00105285
p_int:  0.761078473
p_ni:  0.00043792
p_wrong:  0.238483607
Score:  0.544
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
1
2
53.3
alkaline phosphatase measurement
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
53.3
alkaline phosphatase measurement
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rab acceptor 1
VGNC:8715
740724
Macaque
Rab acceptor 1
706397
Mouse
MGI:1201692
14470
Rat
RGD:621002
83583
Dog
Rab acceptor 1
VGNC:45299
403535
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rab acceptor 1
Macaque
Rab acceptor 1
Mouse
Rat
Dog
Rab acceptor 1
Publication Statistics
PubMed Score 62.19
PubMed score by year
PubTator Score 52.79
PubTator score by year
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Related Publications
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PMID
Year
Title