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Tbio
RAB7B
Ras-related protein Rab-7b

Protein Summary
Description
Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000617070
  • ENSP00000482499
  • ENSG00000276600
  • ENST00000617991
  • ENSP00000479762
  • ENST00000623597
  • ENSP00000485468

Symbol
  • RAB7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.79
molecular function
0.73
cell type or tissue
0.67
tissue
0.66
biological process
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 454.36   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 454.36   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (315)
CHM
Tbio
Family:  Enzyme
Novelty:  0.00226278
p_int:  0.99997953
p_ni:  0.000020469
p_wrong:  1e-9
Score:  0.984
Data Source:  BioPlex,STRINGDB
CHML
Tbio
Family:  Enzyme
Novelty:  0.00509709
p_int:  0.99985143
p_ni:  0.000147907
p_wrong:  6.63e-7
Score:  0.976
Data Source:  BioPlex,STRINGDB
RABGGTA
Tdark
Family:  Enzyme
Novelty:  0.19962321
p_int:  0.999465424
p_ni:  0.000534576
Score:  0.986
Data Source:  BioPlex,STRINGDB
RABGGTB
Tbio
Family:  Enzyme
Novelty:  0.06786314
p_int:  0.992479199
p_ni:  0.007520801
Score:  0.949
Data Source:  BioPlex,STRINGDB
ATE1
Tbio
Family:  Enzyme
Novelty:  0.01672896
p_int:  0.979593642
p_ni:  0.020406358
Score:  0.157
Data Source:  BioPlex,STRINGDB
RILP
Tbio
Novelty:  0.08339816
Score:  0.993
Data Source:  STRINGDB
MON1A
Tbio
Novelty:  0.04537045
Score:  0.991
Data Source:  STRINGDB
MON1B
Tbio
Novelty:  0.13486379
Score:  0.989
Data Source:  STRINGDB
CCZ1B
Tdark
Novelty:  0.09724624
Score:  0.984
Data Source:  STRINGDB
CCZ1
Tbio
Novelty:  0.09830652
Score:  0.984
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
RAB geranylgeranylation
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
Metabolism of proteins
Post-translational protein modification
RAB GEFs exchange GTP for GDP on RABs
RAB geranylgeranylation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cystic fibrosis associated meconium ileus
1
1
0
1.4
48.5
1
1
0
1.4
7.9
1
1
0
1.4
7.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cystic fibrosis associated meconium ileus
0
1.4
48.5
0
1.4
7.9
0
1.4
7.9
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2442295
226421
Rat
RGD:1562617
501854
Cow
RAB7B, member RAS oncogene family
VGNC:33661
538050
Xenopus
RAB7B, member RAS oncogene family
XB-GENE-5824213
100124979
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
RAB7B, member RAS oncogene family
Xenopus
RAB7B, member RAS oncogene family
Publication Statistics
PubMed Score 454.36
PubMed score by year
PubTator Score 264.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title